Abstract p53 is an important tumour suppressor gene, with loss of p53 contributing to the
development of most human cancers. However, the activation of p53 in response to stress …

Estrogens and estrogen receptors (ERs) regulate metabolism in both normal physiology and
in disease. The metabolic characteristics of intrinsic breast cancer subtypes change based …

The hallmarks of cancer capture the most essential phenotypic characteristics of malignant
transformation and progression. Although numerous factors involved in this multi-step …

Metabolic reprogramming is a hallmark of cancer with a strong impact on tumor cell survival,
proliferation, dissemination, and resistance to therapy. As such, it has represented a …

Altered metabolism is a hallmark of cancer and glycolysis is one of the important factors
promoting tumor development. There is however still a lack of molecular characterization …

Metabolic rearrangement is a marker of cancer that has been widely studied in recent years.
One of the major metabolic characteristics of tumor cells is the high levels of glycolysis, even …

Cancer is a complex disease of multiple alterations occuring at the epigenomic, genomic,
transcriptomic, proteomic and/or metabolic levels. The contribution of genetic mutations in …

Nuclear factor erythroid 2-related factor 2 (Nrf2), which regulates the expression of critical
antioxidant proteins, was recently demonstrated to play a key role in cancer progression …

Transketolase (TKT) is an enzyme that is ubiquitously expressed in all living organisms and
has been identified as an important regulator of cancer. Recent studies have shown that the …

Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a key glycolytic enzyme,
plays a crucial role in the energy metabolism of cancer cells and has been proposed as a …