Hyperspectral imaging for clinical applications

J Yoon - BioChip Journal, 2022 - Springer
Measuring morphological and biochemical features of tissue is crucial for disease diagnosis
and surgical guidance, providing clinically significant information related to pathophysiology …

Imagining the future of optical microscopy: everything, everywhere, all at once

H Balasubramanian, CM Hobson, TL Chew… - Communications …, 2023 - nature.com
The optical microscope has revolutionized biology since at least the 17th Century. Since
then, it has progressed from a largely observational tool to a powerful bioanalytical platform …

Phasor plots and the future of spectral and lifetime imaging

L Malacrida - Nature Methods, 2023 - nature.com
Phasor plots and the future of spectral and lifetime imaging | Nature Methods Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Open-source mobile multispectral imaging system and its applications in biological sample sensing

F Shen, H Deng, L Yu, F Cai - Spectrochimica Acta Part A: Molecular and …, 2022 - Elsevier
Visible-near-infrared spectroscopy data can be utilized as an important quantitative indicator
of biomolecular quantitative analysis. When acquiring spectral information, hyperspectral …

Multiplexed bioluminescence microscopy via phasor analysis

Z Yao, CK Brennan, L Scipioni, H Chen, KK Ng… - Nature …, 2022 - nature.com
Bioluminescence imaging with luciferase–luciferin pairs is a well-established technique for
visualizing biological processes across tissues and whole organisms. Applications at the …

More than double the fun with two-photon excitation microscopy

P Luu, SE Fraser, F Schneider - Communications Biology, 2024 - nature.com
For generations researchers have been observing the dynamic processes of life through the
lens of a microscope. This has offered tremendous insights into biological phenomena that …

HyU: Hybrid Unmixing for longitudinal in vivo imaging of low signal-to-noise fluorescence

HJ Chiang, DES Koo, M Kitano, S Burkitt, JR Unruh… - Nature …, 2023 - nature.com
The expansion of fluorescence bioimaging toward more complex systems and geometries
requires analytical tools capable of spanning widely varying timescales and length scales …

Label-free fluorescence microscopy: revisiting the opportunities with autofluorescent molecules and harmonic generations as biosensors and biomarkers for …

MJ García, A Kamaid, L Malacrida - Biophysical Reviews, 2023 - Springer
Over the past decade, the utilization of advanced fluorescence microscopy technologies has
presented numerous opportunities to study or re-investigate autofluorescent molecules and …

The cell physiome: what do we need in a computational physiology framework for predicting single-cell biology?

V Rajagopal, S Arumugam, PJ Hunter… - Annual Review of …, 2022 - annualreviews.org
Modern biology and biomedicine are undergoing a big data explosion, needing advanced
computational algorithms to extract mechanistic insights on the physiological state of living …

Novel opportunities from bioimaging to understand the trafficking and maturation of intracellular pulmonary surfactant and its role in lung diseases

MJ Garcia, L Amarelle, L Malacrida, A Briva - Frontiers in Immunology, 2023 - frontiersin.org
Pulmonary surfactant (PS), a complex mixture of lipids and proteins, is essential for
maintaining proper lung function. It reduces surface tension in the alveoli, preventing …