Design, synthesis, and antifungal evaluation of cryptolepine derivatives against phytopathogenic fungi

YJ Chen, H Liu, SY Zhang, H Li, KY Ma… - Journal of Agricultural …, 2021 - ACS Publications
Inspired by the widely antiphytopathogenic application of diversified derivatives from natural
sources, cryptolepine and its derivatives were subsequently designed, synthesized, and …

Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids

VK Nuthakki, R Mudududdla, SB Bharate - European Journal of Medicinal …, 2022 - Elsevier
Indoloquinoline (IQ) is an important class of naturally occurring antimalarial alkaloids, mainly
represented by cryptolepine, isocryptolepine, and neocryptolepine. The IQ structural …

Design, synthesis, and antimicrobial activity of quindoline derivatives inspired by the cryptolepine alkaloid

QR Chu, YH He, C Tang, ZJ Zhang… - Journal of Agricultural …, 2022 - ACS Publications
Based on the structural characteristics of the cryptolepine alkaloid, a series of new
quindoline derivatives bearing various substituents were prepared and evaluated for their …

A compilation of synthetic strategies to access the most utilized indoloquinoline motifs

C Thongsornkleeb, J Tummatorn… - Chemistry–An Asian …, 2022 - Wiley Online Library
Indoloquinoline alkaloids constitute an important class of aromatic heterocycles consisting of
quinoline and indole fused together in various orientations. These compounds, both natural …

Synthesis and biological evaluation of indoloquinoline alkaloid cryptolepine and its bromo-derivative as dual cholinesterase inhibitors

VK Nuthakki, R Mudududdla, A Sharma, A Kumar… - Bioorganic …, 2019 - Elsevier
Alkaloids have always been a great source of cholinesterase inhibitors. Numerous studies
have shown that inhibiting acetylcholinesterase as well as butyrylcholinetserase is …

Palladium-catalyzed facile synthesis of imidazo [1, 2-a] pyridine-flavone hybrids and evaluation of their antiplasmodial activity

BP Raiguru, J Panda, S Mohapatra, S Nayak - Journal of Molecular …, 2023 - Elsevier
An efficient cross-coupling reaction between imidazo [1, 2-a] pyridine derivatives and 6-
bromoflavones has been well established. This reaction proceeds through a Palladium …

Design, synthesis, Structure‐Activity relationship and docking studies of novel functionalized Arylvinyl‐1, 2, 4‐Trioxanes as potent antiplasmodial as well as anticancer …

MK Tiwari, P Coghi, P Agrawal, BRK Shyamlal… - …, 2020 - Wiley Online Library
A novel series of synthetic functionalized arylvinyl‐1, 2, 4‐trioxanes (8 a–p) has been
prepared and assessed for their in vitro antiplasmodial activity against the chloroquine …

Discovery of cryptolepine derivatives as novel promising agents against phytopathogenic bacteria

YH He, QR Chu, SY Zhang, LR Guo, Y Ma… - Frontiers of Chemical …, 2023 - Springer
To ensure the production of food crops, a series of cryptolepine derivatives were
synthesised, after which their antibacterial activities and mechanism of action against three …

Chitosan-supported FeCl3 catalyzed multicomponent synthesis of tetrahydroisoquinoline-indole hybrids with promising activity against chloroquine resistant …

P Kaur, P Sharma, V Kumar, D Sahal… - Journal of Molecular …, 2023 - Elsevier
An operationally simple three-component coupling of tetrahydroisoquinoline (THIQ),
aldehydes and indoles or indole-3-carboxylic acids has been achieved using chitosan-ionic …

Recent advances in the chemistry and pharmacology of Cryptolepine

SD Shnyder, CW Wright - Progress in the Chemistry of Organic Natural …, 2021 - Springer
Cryptolepine, the principal constituent of the West African climbing shrub Cryptolepis
sanguinolenta, continues to be of interest as a lead to new therapeutic agents, especially for …