The effectiveness of quinolone prophylaxis in high-risk hematological pediatric patients is
controversial. A systematic review was performed according to Preferred Reporting Items for …

Background To be meaningful, a core outcome set (COS) should be relevant to all
stakeholders including patients and carers. This review aimed to explore the methods by …

Background Infection is the most important cause of treatment-related morbidity and
mortality in pediatric patients treated for acute lymphoblastic leukemia (ALL). Although …

Background: Risk-stratified management of fever with neutropenia (FN), allows intensive
management of high-risk cases and early discharge of low-risk cases. No single …

Background In this national multicentre study, we examined the safety of reducing antibiotics
in selected paediatric cancer patients with febrile neutropenia. Methods Patients with signs …

Purpose Prompt antibiotic therapy is standard of care for patients with fever and neutropenia
(FN) during chemotherapy for cancer. We systematically reviewed the association between …

Background Home-based management of low-risk febrile neutropenia (FN) is safe, improves
quality of life and reduces healthcare expenditure. A formal low-risk paediatric program has …

BACKGROUND Evidence to guide treatment of pediatric medium-chain acyl-coenzyme A
dehydrogenase (MCAD) deficiency and phenylketonuria (PKU) is fragmented because of …

Background Numerous paediatric febrile neutropenia (FN) clinical decision rules (CDRs)
have been derived. Validation studies show reduced performance in external settings. We …

Abstract Objectives The Core Outcome Set-STAndards for Development (COS-STAD),
published in 2017, contains 11 standards (12 criteria) describing minimum design criteria for …