Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …

This paper reviews the developments that have occurred in the field of human genetics of
infectious diseases from the second half of the 20th century onward. In particular, it stresses …

The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …

Background Sepsis is one of the main reasons for non-elective admission to pediatric
intensive care units (PICUs), but little is known about determinants influencing outcome. We …

Background Diagnostic delay in common variable immunodeficiency disorders (CVID) is
considerable. There is no generally accepted symptom-recognition framework for its early …

Naturally acquired immunity against invasive pneumococcal disease (IPD) is thought to be
dependent on anti-capsular antibody. However nasopharyngeal colonisation by …

Despite the availability of advances in molecular diagnostic testing for infectious disease,
there is still a need for tools that advance clinical care and public health. Current methods …

Innate immunity contributes to host defense through all cell types and relies on their shared
germline genetic background, whereas adaptive immunity operates through only 3 main cell …

BACKGROUND: The 13-valent pneumococcal conjugate vaccine (PCV13) was licensed in
the United States in 2010. We describe invasive pneumococcal disease (IPD) in children at …

The complement system is crucial for defense against pathogens and the removal of dying
cells or immune complexes. Thus, clinical indications for possible complete complement …