The Wnt signaling pathway, named for its most upstream ligands, the Wnts, is involved in
various differentiation events during embryonic development and leads to tumor formation …

Aberrant activation of the Wnt pathway is implicated in driving the formation of various
human cancers, particularly those of the digestive tract. Inhibition of aberrant Wnt pathway …

Fusobacterium nucleatum (Fn) has been associated with colorectal cancer (CRC), but
causality and underlying mechanisms remain to be established. We demonstrate that Fn …

Aberrant Wnt signaling can drive cancer development. In many cancer types, the genetic
basis of Wnt pathway activation remains incompletely understood. Here, we report recurrent …

Key molecular lesions in colorectal and other cancers cause β-catenin-dependent
transactivation of T cell factor (Tcf)-dependent genes. Disruption of this signal represents an …

Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality
rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new …

The Wnt/β‐catenin signalling and autophagy pathways each play important roles during
development, adult tissue homeostasis and tumorigenesis. Here we identify the Wnt/β …

Background Endometrioid endometrial carcinoma (EEC) is the most common form of
endometrial carcinoma. The heterogeneous clinical course of EEC is an obstacle to …

Mutations of canonical Wnt signaling pathway genes frequently occur in cancer and lead to
abnormal accumulation of the key effector β-catenin. Over the past decades, a number of …

Deregulated Wnt/β-catenin signaling underlies the pathogenesis of a broad range of human
cancers, yet the development of targeted therapies to disrupt the resulting aberrant …