The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …

All organisms possess molecular mechanisms that govern DNA repair and associated DNA
damage response (DDR) processes. Owing to their relevance to human disease, most …

Numerous biologically active metal complexes are reported for their unique features and
enhanced functions, particularly towards the inhibition of cancer progression. With the …

Chemotherapy was conventionally applied to kill cancer cells, but regrettably, they also
induce damage to normal cells with high-proliferative capacity resulting in cardiotoxicity …

Cisplatin spearheads the anticancer chemotherapeutics in present-day use although acute
toxicity is its primary impediment factor. Among a plethora of experimental medications, a …

Countless expectations converge in the multidisciplinary endeavour for the search and
development of effective and safe drugs in fighting cancer. Although they still embody a …

Oxaliplatin was the third Pt-based anticancer drug to be clinically used worldwide. It exhibits
a broad spectrum of anticancer activity and was the first to be approved for the treatment of …

Cisplatin is massively used to treat solid tumors. However, several severe adverse effects,
such as cardiotoxicity, are obstacles to its clinical application. Cardiotoxicity may lead to …

It is well-recognized that cigarette smoking is a primary risk factor in the development of non-
small cell lung cancer (NSCLC), known to account for~ 80% of all lung cancers with nicotine …

Cisplatin has long been a first-line chemotherapeutic agent in the treatment of cancer,
largely for solid tumors. During the course of the past two decades, autophagy has been …