Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …

Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their
sequence homology and functional overlap and co-operation, are emerging as critical …

Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …

Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

Although beta-endorphinergic neurons in the hypothalamic arcuate nucleus (ARC)
synthesize beta-endorphin (β-EP) to alleviate nociceptive behaviors, the underlying …

Epigenetic modifications and metabolism are two fundamental biological processes. During
tumorigenesis and cancer development both epigenetic and metabolic alterations occur and …

Abstract N6-methyladenosine (m6A) RNA methylation and its associated methyltransferase
like 3 (METTL3) are involved in the development and maintenance of various tumors. The …

More than a decade after the launch of DNA methyltransferase and histone deacetylase
inhibitors for the treatment of cancer, 2020 heralded the approval of the first histone …

p300 acts as a transcription coactivator and an acetyltransferase that plays an important role
in tumourigenesis and progression. In previous studies, it has been confirmed that p300 is …