Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …

Glioblastoma multiforme (GBM) is the most common form of brain cancer and one of the
most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be …

Despite all of the progress in understanding its molecular biology and pathogenesis,
glioblastoma (GBM) is one of the most aggressive types of cancers, and without an efficient …

Glioblastoma multiforme (GBM) is among the most incurable cancers. GBMs survival rate
has not markedly improved, despite new radical surgery protocols, the introduction of new …

The highly conserved RAS-mitogen activated protein kinase (MAPK) signaling pathway is
involved in a wide range of cellular processes including differentiation, proliferation, and …

Background Cancer cells possess a common metabolic phenotype, rewiring their metabolic
pathways from mitochondrial oxidative phosphorylation to aerobic glycolysis and anabolic …

Glioblastoma (GBM) stem-like cells (GSC) promote tumor initiation, progression, and
therapeutic resistance. Here, we show how GSCs can be targeted by the FDA-approved …

Epigenetic and metabolic alterations incancer cells are highly associated. Glioblastoma
multiforme (GBM) is a complicated pathological process with dysregulated methylation and …

MicroRNAs (miRNAs) are small noncoding RNAs approximately 20–25 nt in length, which
play crucial roles through directly binding to corresponding 3′ UTR of targeted mRNAs. It …

Epithelial ovarian cancer (EOC) is the most lethal of all gynecologic malignancies. Despite
advances in surgical and chemotherapeutic options, most patients with advanced EOC have …