Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …

Abstract Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …

Gut hormones orchestrate pivotal physiological processes in multiple metabolically active
tissues, including the pancreas, liver, adipose tissue, gut and central nervous system …

Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A
number of new studies have pointed to the potential for conversion of non-β islet cells in to …

The enteroendocrine system orchestrates how the body responds to the ingestion of foods,
employing a diversity of hormones to fine-tune a wide range of physiological responses both …

The preproglucagon gene (Gcg) is expressed by specific enteroendocrine cells (L-cells) of
the intestinal mucosa, pancreatic islet α-cells, and a discrete set of neurons within the …

Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect
disease susceptibility. To describe the human methylome in pancreatic islets and determine …

GLP-1 is an intestinal hormone with widespread actions on metabolism. Therapies based on
GLP-1 are highly effective because they increase glucose-dependent insulin secretion in …

The “second messenger” archetype cAMP is one of the most important cellular signalling
molecules with central functions including the regulation of insulin and glucagon secretion …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …