Resident macrophages play a unique role in the maintenance of tissue function. As
phagocytes, they are an essential first line defenders against pathogens and much of the …

Chitinase-3-like protein 1 (CHI3L1), a chitinase-like protein family member, is a secreted
glycoprotein that mediates macrophage polarization, inflammation, apoptosis, angiogenesis …

Background Reliable biomarkers for organ quality assessment during normothermic
machine perfusion (NMP) are desired. ATP (adenosine triphosphate) production by …

Background Patients with acetaminophen (APAP)-induced acute liver failure (ALF) display
both hyper-and hypocoagulable changes not necessarily recapitulated by standard …

Spatial transcriptomics, which combine gene expression data with spatial information, has
quickly expanded in recent years. With application of this method in liver research, our …

Introduction Phytochemicals present in Moringa oleifera (M. oleifera) leaves have performed
several physiological functions in human system such as anticarcinogenic, antidiabetic …

Acute liver injuries have wide and varied etiologies and they occur both in patients with and
without pre-existent chronic liver disease. Whilst the pathophysiological mechanisms remain …

The liver plays a vital role in metabolism, synthesis, and detoxification, but it is susceptible to
damage from various factors such as viral infections, drug reactions, excessive alcohol …

In many affluent nations, acetaminophen (APAP) overdose is the leading cause of drug-
induced acute liver failure. The process of APAP-induced liver injury (AILI) is intimately tied …

The interaction between the gut microbiota and invariant Natural Killer T (iNKT) cells plays a
pivotal role in colorectal cancer (CRC). The pathobiont Fusobacterium nucleatum influences …