Cell types are the basic building blocks of multicellular organisms and are extensively
diversified in animals. Despite recent advances in characterizing cell types, classification …

Interactions between proteins are orchestrated in a precise and time-dependent manner,
underlying cellular function. The binding affinity, defined as the strength of these …

Motivation Biologists often wish to use their knowledge on a few experimental models of a
given molecular system to identify homologs in genomic data. We developed a generic tool …

Single molecule and NMR measurements of protein dynamics increasingly uncover the
complexity of binding scenarios. Here, we describe an extended conformational selection …

Antibiotic resistance is one of the few examples of evolution that can be addressed
experimentally. The present review analyses this resistance, focusing on the networks that …

Protein complexes are key molecular entities that integrate multiple gene products to
perform cellular functions. The CORUM (http://mips. gsf. de/genre/proj/corum/index. html) …

Protein complexes are assemblies of subunits that have co-evolved to execute one or many
coordinated functions in the cellular environment. Functional annotation of mammalian …

Most of the proteins in a cell assemble into complexes to carry out their function. It is
therefore crucial to understand the physicochemical properties as well as the evolution of …

Cellular processes are typically carried out by protein complexes and functional modules.
Identifying them plays an important role for our attempt to reveal principles of cellular …

A protein-protein interaction (PPI) network is a biomolecule relationship network that plays
an important role in biological activities. Studies of functional modules in a PPI network …