COVID-19 therapeutics: Challenges and directions for the future
PC Robinson, DFL Liew, HL Tanner… - Proceedings of the …, 2022 - National Acad Sciences
The emergence of SARS-CoV-2 triggering the COVID-19 pandemic ranks as arguably the
greatest medical emergency of the last century. COVID-19 has highlighted health disparities …
greatest medical emergency of the last century. COVID-19 has highlighted health disparities …
[HTML][HTML] Metabolic messengers: tumour necrosis factor
JK Sethi, GS Hotamisligil - Nature metabolism, 2021 - nature.com
Tumour necrosis factor (TNF) is a classical, pleiotropic pro-inflammatory cytokine. It is also
the first 'adipokine'described to be produced from adipose tissue, regulated in obesity and …
the first 'adipokine'described to be produced from adipose tissue, regulated in obesity and …
Innate immunological pathways in COVID-19 pathogenesis
SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …
dysregulation of the innate immune system. This knowledge has emerged from the large …
Critical determinants of cytokine storm and type I interferon response in COVID-19 pathogenesis
S Ramasamy, S Subbian - Clinical microbiology reviews, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19), a rapidly evolving pandemic worldwide with at least 68 million …
disease 2019 (COVID-19), a rapidly evolving pandemic worldwide with at least 68 million …
COVID‐19: immunopathology, pathophysiological mechanisms, and treatment options
LE van Eijk, M Binkhorst, AR Bourgonje… - The Journal of …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), continues to spread globally despite the worldwide …
syndrome coronavirus 2 (SARS‐CoV‐2), continues to spread globally despite the worldwide …
[HTML][HTML] COVID-19 in immunocompromised populations: implications for prognosis and repurposing of immunotherapies
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. COVID-19 has highly
variable disease severity and a bimodal course characterized by acute respiratory viral …
variable disease severity and a bimodal course characterized by acute respiratory viral …
[HTML][HTML] The Potential for Repurposing Anti-TNF as a Therapy for the Treatment of COVID-19
Summary Coronavirus disease 2019 (COVID-19) currently has few effective treatments.
Given the uncertainty surrounding the effectiveness and uptake of a vaccine, it is important …
Given the uncertainty surrounding the effectiveness and uptake of a vaccine, it is important …
[HTML][HTML] Dual nature of type I interferons in SARS-CoV-2-induced inflammation
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The ability of our cells to secrete type I …
respiratory syndrome coronavirus 2 (SARS-CoV-2). The ability of our cells to secrete type I …
COVID-19: inflammatory profile
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of
coronavirus disease 2019 (COVID-19), has resulted in a pandemic that has had widespread …
coronavirus disease 2019 (COVID-19), has resulted in a pandemic that has had widespread …
Inflammation at the crossroads of COVID-19, cognitive deficits and depression
NML e Silva, FGQ Barros-Aragão, FG De Felice… - …, 2022 - Elsevier
Acute neurological alterations have been associated with SARS-CoV-2 infection.
Additionally, it is becoming clear that coronavirus disease 2019 (COVID-19) survivors may …
Additionally, it is becoming clear that coronavirus disease 2019 (COVID-19) survivors may …