Role of pyroptosis in cardiovascular disease
Z Zhaolin, L Guohua, W Shiyuan, W Zuo - Cell proliferation, 2019 - Wiley Online Library
Cardiac function is determined by the dynamic equilibrium of various cell types and the
extracellular matrix that composes the heart. Cardiovascular diseases (CVDs), especially …
extracellular matrix that composes the heart. Cardiovascular diseases (CVDs), especially …
The RNA-binding protein HuR in human cancer: a friend or foe?
The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …
elements present in mRNAs whose stability and translation are subject to regulation. The …
A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus
Long non-coding RNAs (lncRNAs) are emerging regulators of pathophysiological processes
including atherosclerosis. Using RNA-seq profiling of the intima of lesions, here we identify a …
including atherosclerosis. Using RNA-seq profiling of the intima of lesions, here we identify a …
LincRNA-p21 suppresses target mRNA translation
JH Yoon, K Abdelmohsen, S Srikantan, X Yang… - Molecular cell, 2012 - cell.com
Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating
transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of …
transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of …
Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR
S Lebedeva, M Jens, K Theil, B Schwanhäusser… - Molecular cell, 2011 - cell.com
Posttranscriptional gene regulation relies on hundreds of RNA binding proteins (RBPs) but
the function of most RBPs is unknown. The human RBP HuR/ELAVL1 is a conserved mRNA …
the function of most RBPs is unknown. The human RBP HuR/ELAVL1 is a conserved mRNA …
The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r
A Keniry, D Oxley, P Monnier, M Kyba, L Dandolo… - Nature cell …, 2012 - nature.com
The H19 large intergenic non-coding RNA (lincRNA) is one of the most highly abundant and
conserved transcripts in mammalian development, being expressed in both embryonic and …
conserved transcripts in mammalian development, being expressed in both embryonic and …
Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability
RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying
these global interactions remain poorly understood. We elucidated regulatory mechanisms …
these global interactions remain poorly understood. We elucidated regulatory mechanisms …
ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy
HY Chen, ZZ Xiao, X Ling, RN Xu, P Zhu, SY Zheng - Molecular Medicine, 2021 - Springer
Aims Myocardial ischemia is the most common form of cardiovascular disease and the
leading cause of morbidity and mortality. Understanding the mechanisms is very crucial for …
leading cause of morbidity and mortality. Understanding the mechanisms is very crucial for …
The RNA-binding protein HuR is essential for the B cell antibody response
Post-transcriptional regulation of mRNA by the RNA-binding protein HuR (encoded by
Elavl1) is required in B cells for the germinal center reaction and for the production of class …
Elavl1) is required in B cells for the germinal center reaction and for the production of class …
Emerging roles for RNA-binding proteins as effectors and regulators of cardiovascular disease
RG de Bruin, TJ Rabelink… - European heart …, 2017 - academic.oup.com
The cardiovascular system comprises multiple cell types that possess the capacity to
modulate their phenotype in response to acute or chronic injury. Transcriptional and post …
modulate their phenotype in response to acute or chronic injury. Transcriptional and post …