Endophytic fungi: from symbiosis to secondary metabolite communications or vice versa?

B Alam, J Lǐ, Q Gě, MA Khan, J Gōng… - Frontiers in Plant …, 2021 - frontiersin.org
Endophytic fungi (EF) are a group of fascinating host-associated fungal communities that
colonize the intercellular or intracellular spaces of host tissues, providing beneficial effects to …

Fungal secondary metabolism: regulation, function and drug discovery

NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and …

JC Frisvad, LLH Møller, TO Larsen, R Kumar… - Applied Microbiology …, 2018 - Springer
This review presents an update on the current knowledge of the secondary metabolite
potential of the major fungal species used in industrial biotechnology, ie, Aspergillus niger …

Aspergillus fumigatus pan-genome analysis identifies genetic variants associated with human infection

AE Barber, T Sae-Ong, K Kang, B Seelbinder, J Li… - Nature …, 2021 - nature.com
Aspergillus fumigatus is an environmental saprobe and opportunistic human fungal
pathogen. Despite an estimated annual occurrence of more than 300,000 cases of invasive …

The birth, evolution and death of metabolic gene clusters in fungi

A Rokas, JH Wisecaver, AL Lind - Nature Reviews Microbiology, 2018 - nature.com
Fungi contain a remarkable diversity of both primary and secondary metabolic pathways
involved in ecologically specialized or accessory functions. Genes in these pathways are …

Metabolic gene clusters in eukaryotes

HW Nützmann, C Scazzocchio… - Annual Review of …, 2018 - annualreviews.org
In bacteria, more than half of the genes in the genome are organized in operons. In contrast,
in eukaryotes, functionally related genes are usually dispersed across the genome. There …

Genomes and secretomes of Ascomycota fungi reveal diverse functions in plant biomass decomposition and pathogenesis

JF Challacombe, CN Hesse, LM Bramer, LA McCue… - BMC genomics, 2019 - Springer
Background The dominant fungi in arid grasslands and shrublands are members of the
Ascomycota phylum. Ascomycota fungi are important drivers in carbon and nitrogen cycling …

Biosynthetic gene clusters and the evolution of fungal chemodiversity

A Rokas, ME Mead, JL Steenwyk, HA Raja… - Natural product …, 2020 - pubs.rsc.org
Covering: up to 2019 Fungi produce a remarkable diversity of secondary metabolites: small,
bioactive molecules not required for growth but which are essential to their ecological …

[HTML][HTML] Developing fungal heterologous expression platforms to explore and improve the production of natural products from fungal biodiversity

X Meng, Y Fang, M Ding, Y Zhang, K Jia, Z Li… - Biotechnology …, 2022 - Elsevier
Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …

Formation and diversification of a paradigm biosynthetic gene cluster in plants

Z Liu, J Cheema, M Vigouroux, L Hill, J Reed… - Nature …, 2020 - nature.com
Numerous examples of biosynthetic gene clusters (BGCs), including for compounds of
agricultural and medicinal importance, have now been discovered in plant genomes …