Mitochondrial DNA in inflammation and immunity
Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …
from energy production and metabolism to cell death and inflammation. Despite this …
[HTML][HTML] Intercellular mitochondrial transfer as a means of tissue revitalization
D Liu, Y Gao, J Liu, Y Huang, J Yin, Y Feng… - Signal transduction and …, 2021 - nature.com
As the crucial powerhouse for cell metabolism and tissue survival, the mitochondrion
frequently undergoes morphological or positional changes when responding to various …
frequently undergoes morphological or positional changes when responding to various …
[HTML][HTML] GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity
The transfer of intact mitochondria between heterogeneous cell types has been confirmed in
various settings, including cancer. However, the functional implications of mitochondria …
various settings, including cancer. However, the functional implications of mitochondria …
[HTML][HTML] Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management
Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …
underlying stress adaptation of cancer cells in response to therapy-induced hostile …
[PDF][PDF] Intercellular mitochondria transfer to macrophages regulates white adipose tissue homeostasis and is impaired in obesity
Recent studies suggest that mitochondria can be transferred between cells to support the
survival of metabolically compromised cells. However, whether intercellular mitochondria …
survival of metabolically compromised cells. However, whether intercellular mitochondria …
[HTML][HTML] Mitochondrial metabolism and cancer
Glycolysis has long been considered as the major metabolic process for energy production
and anabolic growth in cancer cells. Although such a view has been instrumental for the …
and anabolic growth in cancer cells. Although such a view has been instrumental for the …
[HTML][HTML] Molecular mechanisms of mtDNA-mediated inflammation
A De Gaetano, K Solodka, G Zanini, V Selleri… - Cells, 2021 - mdpi.com
Besides their role in cell metabolism, mitochondria display many other functions.
Mitochondrial DNA (mtDNA), the own genome of the organelle, plays an important role in …
Mitochondrial DNA (mtDNA), the own genome of the organelle, plays an important role in …
[HTML][HTML] The significance of mitochondrial dysfunction in cancer
As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in
energy metabolism, maintenance of redox balance, and regulation of apoptosis …
energy metabolism, maintenance of redox balance, and regulation of apoptosis …
[HTML][HTML] Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases
Z Liu, Y Sun, Z Qi, L Cao, S Ding - Cell & bioscience, 2022 - Springer
Mitochondria play a pivotal role in energy generation and cellular physiological processes.
These organelles are highly dynamic, constantly changing their morphology, cellular …
These organelles are highly dynamic, constantly changing their morphology, cellular …
[HTML][HTML] Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs
K Todkar, L Chikhi, V Desjardins, F El-Mortada… - Nature …, 2021 - nature.com
Most cells constitutively secrete mitochondrial DNA and proteins in extracellular vesicles
(EVs). While EVs are small vesicles that transfer material between cells, Mitochondria …
(EVs). While EVs are small vesicles that transfer material between cells, Mitochondria …