Thiol-mediated uptake
This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells
enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive …
enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive …
[HTML][HTML] The groovy TMEM16 family: molecular mechanisms of lipid scrambling and ion conduction
V Kalienkova, VC Mosina, C Paulino - Journal of Molecular Biology, 2021 - Elsevier
The TMEM16 family of membrane proteins displays a remarkable functional dichotomy–
while some family members function as Ca 2+-activated anion channels, the majority of …
while some family members function as Ca 2+-activated anion channels, the majority of …
Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase
The dual functions of TMEM16F as Ca2+-activated ion channel and lipid scramblase raise
intriguing questions regarding their molecular basis. Intrigued by the ability of the FDA …
intriguing questions regarding their molecular basis. Intrigued by the ability of the FDA …
Flagging fusion: Phosphatidylserine signaling in cell–cell fusion
JM Whitlock, LV Chernomordik - Journal of Biological Chemistry, 2021 - ASBMB
Formations of myofibers, osteoclasts, syncytiotrophoblasts, and fertilized zygotes share a
common step, cell–cell fusion. Recent years have brought about considerable progress in …
common step, cell–cell fusion. Recent years have brought about considerable progress in …
Cryo-EM studies of TMEM16F calcium-activated ion channel suggest features important for lipid scrambling
As a Ca 2+-activated lipid scramblase and ion channel that mediates Ca 2+ influx,
TMEM16F relies on both functions to facilitate extracellular vesicle generation, blood …
TMEM16F relies on both functions to facilitate extracellular vesicle generation, blood …
Critical role of lipid scramblase TMEM16F in phosphatidylserine exposure and repair of plasma membrane after pore formation
N Wu, V Cernysiov, D Davidson, H Song, J Tang, S Luo… - Cell reports, 2020 - cell.com
Plasma membrane damage and cell death during processes such as necroptosis and
apoptosis result from cues originating intracellularly. However, death caused by pore …
apoptosis result from cues originating intracellularly. However, death caused by pore …
Structural heterogeneity of the ion and lipid channel TMEM16F
Z Ye, N Galvanetto, L Puppulin, S Pifferi… - Nature …, 2024 - nature.com
Abstract Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which
functions as an ion channel and a phospholipid scramblase. Despite the availability of …
functions as an ion channel and a phospholipid scramblase. Despite the availability of …
Contribution of anoctamins to cell survival and cell death
K Kunzelmann, J Ousingsawat, R Benedetto, I Cabrita… - Cancers, 2019 - mdpi.com
Before anoctamins (TMEM16 proteins) were identified as a family of Ca2+-activated chloride
channels and phospholipid scramblases, the founding member anoctamin 1 (ANO1 …
channels and phospholipid scramblases, the founding member anoctamin 1 (ANO1 …
Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion
Abstract TMEM16F, a Ca 2+-activated phospholipid scramblase (CaPLSase), is critical for
placental trophoblast syncytialization, HIV infection, and SARS-CoV2-mediated …
placental trophoblast syncytialization, HIV infection, and SARS-CoV2-mediated …
Regulation of membrane homeostasis by TMC1 mechanoelectrical transduction channels is essential for hearing
A Ballesteros, KJ Swartz - Science Advances, 2022 - science.org
The mechanoelectrical transduction (MET) channel in auditory hair cells converts sound into
electrical signals, enabling hearing. Transmembrane-like channel 1 and 2 (TMC1 and …
electrical signals, enabling hearing. Transmembrane-like channel 1 and 2 (TMC1 and …