Dysregulation of host cell calcium signaling during viral infections: Emerging paradigm with high clinical relevance

S Saurav, J Tanwar, K Ahuja, RK Motiani - Molecular aspects of medicine, 2021 - Elsevier
Viral infections are one of the leading causes of human illness. Viruses take over host cell
signaling cascades for their replication and infection. Calcium (Ca 2+) is a versatile and …

Developing novel antifungals: lessons from G protein-coupled receptors

V Velazhahan, BL McCann, E Bignell… - Trends in pharmacological …, 2023 - cell.com
Up to 1.5 million people die yearly from fungal disease, but the repertoire of antifungal drug
classes is minimal and the incidence of drug resistance is rising rapidly. This dilemma was …

CFTR inhibitors display in vitro antiviral activity against SARS-CoV-2

A Lagni, V Lotti, E Diani, G Rossini, E Concia, C Sorio… - Cells, 2023 - mdpi.com
Several reports have indicated that SARS-CoV-2 infection displays unexpected mild clinical
manifestations in people with cystic fibrosis (pwCF), suggesting that CFTR expression and …

Unmasking Pandemic Echoes: An In-Depth Review of Long COVID's Unabated Cardiovascular Consequences beyond 2020

ML Luchian, J Higny, M Benoit, B Robaye, Y Berners… - Diagnostics, 2023 - mdpi.com
At the beginning of 2020, coronavirus disease 2019 (COVID-19) emerged as a new
pandemic, leading to a worldwide health crisis and overwhelming healthcare systems due to …

Down the membrane hole: Ion channels in protozoan parasites

V Jimenez, S Mesones - PLoS pathogens, 2022 - journals.plos.org
Parasitic diseases caused by protozoans are highly prevalent around the world,
disproportionally affecting developing countries, where coinfection with other …

Influenza virus uses mGluR2 as an endocytic receptor to enter cells

Z Ni, J Wang, X Yu, Y Wang, J Wang, X He, C Li… - Nature …, 2024 - nature.com
Influenza virus infection is initiated by the attachment of the viral haemagglutinin (HA)
protein to sialic acid receptors on the host cell surface. Most virus particles enter cells …

Modulation of adaptive immunity and viral infections by ion channels

K Bohmwald, NMS Gálvez, CA Andrade… - Frontiers in …, 2021 - frontiersin.org
Most cellular functions require of ion homeostasis and ion movement. Among others, ion
channels play a crucial role in controlling the homeostasis of anions and cations …

[HTML][HTML] Chloride channels in the lung: Challenges and perspectives for viral infections, pulmonary arterial hypertension, and cystic fibrosis

M Sinha, D Zabini, D Guntur, C Nagaraj… - Pharmacology & …, 2022 - Elsevier
Fine control over chloride homeostasis in the lung is required to maintain membrane
excitability, transepithelial transport as well as intra-and extracellular ion and water …

Kv1.3-induced hyperpolarization is required for efficient Kaposi's sarcoma–associated herpesvirus lytic replication

H Carden, KL Harper, TJ Mottram, O Manners… - Science …, 2024 - science.org
Kaposi's sarcoma–associated herpesvirus (KSHV) is an oncogenic herpesvirus that is linked
directly to the development of Kaposi's sarcoma. KSHV establishes a latent infection in B …

COVID-19: the CaMKII-like system of S protein drives membrane fusion and induces syncytial multinucleated giant cells

L Wenzhong, L Hualan - Immunologic research, 2021 - Springer
Abstract The SARS-CoV-2 S protein on the membrane of infected cells can promote receptor-
dependent syncytia formation, relating to extensive tissue damage and lymphocyte …