Lung cancer is the primary cause of mortality in the United States and around the globe.
Therapeutic options for lung cancer treatment include surgery, radiation therapy …

The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Dysregulation of the Notch signaling pathway, which is highly conserved across species,
can drive aberrant epigenetic modification, transcription, and translation. Defective gene …

Small cell lung cancer (SCLC) is an aggressive neuroendocrine carcinoma with a poor
prognosis. Initial responses to standard-of-care chemo-immunotherapy are, unfortunately …

Precision medicine describes a target-related approach to tailoring diagnosis and treatment
of the individual patient. While this personalized approach is revoluzionizing many areas of …

The DLL/Notch signaling pathway plays an important role in cancer as a key driver in
maintaining cancer stemness and inducing tumor angiogenesis. Many different types of …

Effective treatments for de novo and treatment-emergent small-cell/neuroendocrine (t-
SCNC) prostate cancer represent an unmet need for this disease. Using metastatic biopsies …

Notch and Hedgehog signaling are involved in cancer biology and pathology, including the
maintenance of tumor cell proliferation, cancer stem-like cells, and the tumor …

The current standard-of-care for the treatment of advanced non-small cell lung cancer
(NSCLC) incorporates targeted therapies, immune-checkpoint inhibitors (ICI) and systemic …

Simple Summary The Notch signaling pathway regulates cell proliferation, apoptosis, stem
cell self-renewal, and differentiation in a context-dependent fashion both during embryonic …