Does functional specialization of ribosomes really exist?

MB Ferretti, K Karbstein - Rna, 2019 - rnajournal.cshlp.org
It has recently become clear that ribosomes are much more heterogeneous than previously
thought, with diversity arising from rRNA sequence and modifications, ribosomal protein …

[HTML][HTML] Bacterial toxin-antitoxin systems: Novel insights on toxin activation across populations and experimental shortcomings

LR Pizzolato-Cezar, B Spira, MT Machini - Current Research in Microbial …, 2023 - Elsevier
The alarming rise in hard-to-treat bacterial infections is of great concern to human health.
Thus, the identification of molecular mechanisms that enable the survival and growth of …

Proteomic Investigation of Tolerant Escherichia coli Populations from Cyclic Antibiotic Treatment

JE Sulaiman, H Lam - Journal of proteome research, 2020 - ACS Publications
Persisters are a subpopulation of cells that have enhanced abilities to survive antibiotics and
other stressful conditions. Recently, it was found that when persisters were repeatedly …

Noise minimization in cell-free gene expression

MW Bartelds, Ó García-Blay, PGA Verhagen… - ACS Synthetic …, 2023 - ACS Publications
Biochemical reactions that involve small numbers of molecules are accompanied by a
degree of inherent randomness that results in noisy reaction outcomes. In synthetic biology …

Integrative biology of persister cell formation: molecular circuitry, phenotypic diversification and fitness effects

A Berkvens, P Chauhan… - Journal of the Royal …, 2022 - royalsocietypublishing.org
Microbial populations often contain persister cells, which reduce the extinction risk upon
sudden stresses. Persister cell formation is deeply intertwined with physiology. Due to this …

Autoregulation of mazEF expression underlies growth heterogeneity in bacterial populations

N Nikolic, T Bergmiller, A Vandervelde… - Nucleic Acids …, 2018 - academic.oup.com
The MazF toxin sequence-specifically cleaves single-stranded RNA upon various stressful
conditions, and it is activated as a part of the mazEF toxin–antitoxin module in Escherichia …

Autoregulation of bacterial gene expression: lessons from the MazEF toxin–antitoxin system

N Nikolic - Current Genetics, 2019 - Springer
Autoregulation is the direct modulation of gene expression by the product of the
corresponding gene. Autoregulation of bacterial gene expression has been mostly studied …

Engineering the translational machinery for biotechnology applications

T Wang, C Liang, Y An, S Xiao, H Xu, M Zheng… - Molecular …, 2020 - Springer
The ribosome is an essential organelle in charge of the translational processes in all kinds
of cells. Currently, the scenario of its function has been significantly expanded from the …

Bacterial toxin-antitoxin system MazEF as a native defense mechanism against RNA phages in Escherichia coli

N Nikolic, T Bergmiller, M Pleška, CC Guet - bioRxiv, 2023 - biorxiv.org
Bacteria have evolved a wide range of defense strategies to protect themselves against
bacterial viruses (phages). However, the known mechanisms almost exclusively target …

Deciphering the antitoxin-regulated bacterial stress response via single-cell analysis

L Wu, M Zhang, Y Song, M Deng, S He, L Su… - ACS chemical …, 2019 - ACS Publications
Bacterial toxin–antitoxin (TA) systems, which are diverse and widespread among
prokaryotes, are responsible for tolerance to drugs and environmental stresses. However …