The neocortex is a complex neurobiological system with many interacting regions. How
these regions work together to subserve flexible behavior and cognition has become …

Electron microscopy (EM) is widely used for studying cellular structure and network
connectivity in the brain. We have built a parallel imaging pipeline using transmission …

Isotropic high-resolution imaging of large volumes provides unprecedented opportunities to
advance connectomics and cell biology research. Conventional focused ion beam scanning …

Recent advances in brain imaging allow producing large amounts of 3-D volumetric data
from which morphometry data is reconstructed and measured. Fine detailed structural …

Dissociation between the output of the circadian clock and external environmental cues is a
major cause of human cognitive dysfunction. While the effects of ablation of the molecular …

Identifying the direction of signal flows in neural networks is important for understanding the
intricate information dynamics of a living brain. Using a dataset of 213 projection neurons …

Memory-relevant neuronal plasticity is believed to require local translation of new proteins at
synapses. Understanding this process requires the visualization of the relevant mRNAs …

Tridimensional microscopy and algorithms for automated segmentation and tracing are
revolutionizing neuroscience through the generation of growing libraries of neuron …

The advent of large-scale microscopy along with advances in automated image analysis
algorithms is currently revolutionizing neuroscience. These approaches result in rapidly …

To navigate through the environment, animals use visual feedback to control their movement
relative to their surroundings. Despite decades of efforts to study how the brain achieves this …