The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and
bristle polarity [[1],[2],[3]]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates …

IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the
formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and …

Since its discovery in 1994, recognized cellular functions for the scaffold protein IQGAP1
have expanded immensely. Over 100 unique IQGAP1-interacting proteins have been …

Simple Summary IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a signal
scaffolding protein that regulates a range of cellular activities by facilitating signal …

The intracellular spatiotemporal organization of signaling events is critical for normal cellular
function. In response to environmental stimuli, cells utilize highly organized signaling …

Robinow syndrome (RS) is a phenotypically and genetically heterogeneous condition that
can be caused by mutations in genes encoding components of the non-canonical Wnt …

R-spondins (RSPOs) and their receptor leucine-rich repeat-containing G-protein coupled
receptor 4 (LGR4) play pleiotropic roles in normal and cancer development as well as the …

IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a scaffold protein that
participates in several cellular functions, including cytoskeletal regulation, cell adhesion …

Glioma is one of the most common neoplasms of the central nervous system with a poor
survival. Due to the obstacles in treating this disease, a part of recent studies mainly focuses …

In contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin,
which is a prerequisite for formation of the TCF4/β-catenin transcriptional complex and …