Tumor necrosis factor (TNF)-α is a potent pro-inflammatory and pathological cytokines in
inflammatory diseases such as rheumatoid arthritis and inflammatory bowel diseases. Anti …

Transmembrane TNF-α, a precursor of the soluble form of TNF-α, is expressed on activated
macrophages and lymphocytes as well as other cell types. After processing by TNF-α …

The role of tumor necrosis factor (TNF) as an immune mediator has long been appreciated
but its function in the brain is still unclear. TNF receptor 1 (TNFR1) is expressed in most cell …

Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most widespread
neurological disorders (NDs) characterized by degeneration of cognitive and motor …

The inflammatory cytokine tumor necrosis factor (TNF), as well as most other ligand
members of the TNF superfamily, exist both as classical soluble cytokines, but also in the …

Biotherapies have revolutionized the treatment of RA. However, much work is needed to
understand all the mechanisms of these biotherapies, and alternatives are needed to …

Homologues of signal peptide peptidase (SPPLs) are putative aspartic proteases that may
catalyse regulated intramembrane proteolysis of type II membrane-anchored signalling …

ABSTRACT CD137 (4-1BB, TNFR superfamily 9) and its ligand are members of the TNFR
and TNF families, respectively, and are involved in the regulation of a wide range of immune …

TNF antagonists may offer therapeutic potential in solid tumors, but patients who have high
serum levels of TNF-α fail to respond to infliximab, suggesting consumption of the circulating …

Tumor necrosis factor (TNF)-α is a potent pro-inflammatory cytokine exerting pleiotropic
effects on various cell types. It is synthesized in a precursor form called transmembrane TNF …