Population genomics of Klebsiella pneumoniae

KL Wyres, MMC Lam, KE Holt - Nature Reviews Microbiology, 2020 - nature.com
Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

Plant NLR diversity: the known unknowns of pan-NLRomes

AC Barragan, D Weigel - The Plant Cell, 2021 - academic.oup.com
Plants and pathogens constantly adapt to each other. As a consequence, many members of
the plant immune system, and especially the intracellular nucleotide-binding site leucine …

A genomic catalogue of soil microbiomes boosts mining of biodiversity and genetic resources

B Ma, C Lu, Y Wang, J Yu, K Zhao, R Xue… - Nature …, 2023 - nature.com
Soil harbors a vast expanse of unidentified microbes, termed as microbial dark matter,
presenting an untapped reservoir of microbial biodiversity and genetic resources, but has …

Genetic innovations in animal–microbe symbioses

J Perreau, NA Moran - Nature Reviews Genetics, 2022 - nature.com
Animal hosts have initiated myriad symbiotic associations with microorganisms and often
have maintained these symbioses for millions of years, spanning drastic changes in …

The role of integrative and conjugative elements in antibiotic resistance evolution

J Botelho, H Schulenburg - Trends in microbiology, 2021 - cell.com
Mobile genetic elements (MGEs), such as plasmids and integrative and conjugative
elements (ICEs), are main drivers for the spread of antibiotic resistance (AR). Coevolution …

Selfish, promiscuous and sometimes useful: how mobile genetic elements drive horizontal gene transfer in microbial populations

M Haudiquet, JM de Sousa… - … Transactions of the …, 2022 - royalsocietypublishing.org
Horizontal gene transfer (HGT) drives microbial adaptation but is often under the control of
mobile genetic elements (MGEs) whose interests are not necessarily aligned with those of …

Microbiome interconnectedness throughout environments with major consequences for healthy people and a healthy planet

A Sessitsch, S Wakelin, M Schloter… - Microbiology and …, 2023 - Am Soc Microbiol
Microbiomes have highly important roles for ecosystem functioning and carry out key
functions that support planetary health, including nutrient cycling, climate regulation, and …

Landscape of mobile genetic elements and their antibiotic resistance cargo in prokaryotic genomes

S Khedkar, G Smyshlyaev, I Letunic… - Nucleic acids …, 2022 - academic.oup.com
Abstract Prokaryotic Mobile Genetic Elements (MGEs) such as transposons, integrons,
phages and plasmids, play important roles in prokaryotic evolution and in the dispersal of …

PPanGGOLiN: depicting microbial diversity via a partitioned pangenome graph

G Gautreau, A Bazin, M Gachet, R Planel… - PLoS computational …, 2020 - journals.plos.org
The use of comparative genomics for functional, evolutionary, and epidemiological studies
requires methods to classify gene families in terms of occurrence in a given species. These …

Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria

YM Shi, M Hirschmann, YN Shi, S Ahmed… - Nature Chemistry, 2022 - nature.com
Microorganisms contribute to the biology and physiology of eukaryotic hosts and affect other
organisms through natural products. Xenorhabdus and Photorhabdus (XP) living in …