Large-conductance Ca2+ release channels known as ryanodine receptors (RyRs) mediate
the release of Ca2+ from an intracellular membrane compartment, the endo/sarcoplasmic …

Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle triggered by
volatile anesthetics or succinylcholine. It manifests as a potentially lethal hypermetabolic …

The type-1 ryanodine receptor (RyR1) is an intracellular calcium (Ca 2+) release channel
required for skeletal muscle contraction. Here, we present cryo-EM reconstructions of RyR1 …

The ryanodine receptors (RyRs) are intracellular calcium channels responsible for rapid
release of Ca 2+ from the sarcoplasmic/endoplasmic reticulum (SR/ER) to the cytoplasm …

Ryanodine receptors (RyRs) are a class of giant ion channels with molecular mass over 2.2
mega-Daltons. These channels mediate calcium signaling in a variety of cells. Since more …

The excitation–contraction coupling (ECC) in skeletal muscle refers to the Ca2+-mediated
link between the membrane excitation and the mechanical contraction. The initiation and …

Ginsenoside-Rb1 (Rb1), a major active component of ginseng, has many benefits for
cardiovascular disease and diabetes mellitus (DM), but the effect and mechanism on …

Background Pathogenic variations in the gene encoding the skeletal muscle ryanodine
receptor (RyR1) are associated with malignant hyperthermia (MH) susceptibility, a life …

Understanding how the nervous system bridges sensation and behavior requires the
elucidation of complex neural and molecular networks. Forward genetic approaches, such …

Cardiac arrhythmias are serious, life-threatening diseases associated with the dysregulation
of Ca 2+ influx into the cytoplasm of cardiomyocytes. This dysregulation often arises from …