Mechanisms of stem cell therapy in spinal cord injuries

M Shinozaki, N Nagoshi, M Nakamura, H Okano - Cells, 2021 - mdpi.com
Every year, 0.93 million people worldwide suffer from spinal cord injury (SCI) with
irretrievable sequelae. Rehabilitation, currently the only available treatment, does not …

Myelin status and oligodendrocyte lineage cells over time after spinal cord injury: What do we know and what still needs to be unwrapped?

N Pukos, MT Goodus, FR Sahinkaya, DM McTigue - Glia, 2019 - Wiley Online Library
Spinal cord injury (SCI) affects over 17,000 individuals in the United States per year,
resulting in sudden motor, sensory and autonomic impairments below the level of injury …

DLP printed hDPSC-loaded GelMA microsphere regenerates dental pulp and repairs spinal cord

Y Qian, J Gong, K Lu, Y Hong, Z Zhu, J Zhang, Y Zou… - Biomaterials, 2023 - Elsevier
Dental pulp regeneration is ideal for irreversible pulp or periapical lesions, and in situ stem
cell therapy is one of the most effective therapies for pulp regeneration. In this study, we …

Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury

JL Nielson, J Paquette, AW Liu, CF Guandique… - Nature …, 2015 - nature.com
Data-driven discovery in complex neurological disorders has potential to extract meaningful
syndromic knowledge from large, heterogeneous data sets to enhance potential for …

Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury

CL Walker, MJ Walker, NK Liu, EC Risberg, X Gao… - PLoS …, 2012 - journals.plos.org
Secondary damage following primary spinal cord injury extends pathology beyond the site
of initial trauma, and effective management is imperative for maximizing anatomical and …

Experimental spinal cord injury and behavioral tests in laboratory rats

RU Ahmed, M Alam, YP Zheng - Heliyon, 2019 - cell.com
Traumatic spinal cord injury (SCI) results in some serious neurophysiological consequences
that alter healthy body functions and devastate the quality of living of individuals. To find a …

Protective Mechanism of Stem Cells from Human Exfoliated Deciduous Teeth in Treating Spinal Cord Injury

T Nishii, K Osuka, Y Nishimura, Y Ohmichi… - Journal of …, 2024 - liebertpub.com
Spinal cord injury (SCI) induces devastating permanent deficits. Recently, cell
transplantation therapy has become a notable treatment for SCI. Although stem cells from …

Precise control of miR-125b levels is required to create a regeneration-permissive environment after spinal cord injury: a cross-species comparison between …

JF Diaz Quiroz, E Tsai, M Coyle… - Disease models & …, 2014 - journals.biologists.com
Most spinal cord injuries lead to permanent paralysis in mammals. By contrast, the
remarkable regenerative abilities of salamanders enable full functional recovery even from …

Characterization of a graded cervical hemicontusion spinal cord injury model in adult male rats

KA Dunham, A Siriphorn, S Chompoopong… - Journal of …, 2010 - liebertpub.com
Most experimental models of spinal cord injury (SCI) in rodents induce damage in the
thoracic cord and subsequently examine hindlimb function as an indicator of recovery. In …

Ipsilesional motor cortex plasticity participates in spontaneous hindlimb recovery after lateral hemisection of the thoracic spinal cord in the rat

AR Brown, M Martinez - Journal of Neuroscience, 2018 - Soc Neuroscience
After an incomplete spinal cord injury (SCI) spontaneous motor recovery can occur in
mammals, but the underlying neural substrates remain poorly understood. The motor cortex …