The actin cytoskeleton—a collection of actin filaments with their accessory and regulatory
proteins—is the primary force-generating machinery in the cell. It can produce pushing …

Cells can detect and react to the biophysical properties of the extracellular environment
through integrin-based adhesion sites and adapt to the extracellular milieu in a process …

Cell adhesion is essential in cell communication and regulation, and is of fundamental
importance in the development and maintenance of tissues. The mechanical interactions …

Forces generated by cells are critical regulators of cell adhesion, signaling, and function,
and they are also essential drivers in the morphogenetic events of development. Over the …

Stem cells respond to nanoscale surface features, with changes in cell growth and
differentiation mediated by alterations in cell adhesion. The interaction of nanotopographical …

Stress fibers and focal adhesions are complex protein arrays that produce, transmit and
sense mechanical tension. Evidence accumulated over many years led to the conclusion …

Simple Summary The cytoskeleton is a network of protein fibres within cells that provide
structure and support intracellular transport. Focal adhesions are protein complexes …

Metastasis is a complex, multistep process responsible for> 90% of cancer-related deaths. In
addition to genetic and external environmental factors, the physical interactions of cancer …

Directed cell migration is critical for embryogenesis and organ development, wound healing
and the immune response. Microtubules are dynamic polymers that control directional …

Non-muscle myosin II (NM II) is an actin-binding protein that has actin cross-linking and
contractile properties and is regulated by the phosphorylation of its light and heavy chains …