Microbiome-based therapeutics

MT Sorbara, EG Pamer - Nature Reviews Microbiology, 2022 - nature.com
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …

Prevotella diversity, niches and interactions with the human host

A Tett, E Pasolli, G Masetti, D Ercolini… - Nature Reviews …, 2021 - nature.com
The genus Prevotella includes more than 50 characterized species that occur in varied
natural habitats, although most Prevotella spp. are associated with humans. In the human …

Cardiometabolic health, diet and the gut microbiome: a meta-omics perspective

M Valles-Colomer, C Menni, SE Berry, AM Valdes… - Nature Medicine, 2023 - nature.com
Cardiometabolic diseases have become a leading cause of morbidity and mortality globally.
They have been tightly linked to microbiome taxonomic and functional composition, with diet …

The Prevotella copri complex comprises four distinct clades underrepresented in westernized populations

A Tett, KD Huang, F Asnicar, H Fehlner-Peach… - Cell host & …, 2019 - cell.com
Prevotella copri is a common human gut microbe that has been both positively and
negatively associated with host health. In a cross-continent meta-analysis exploiting> 6,500 …

Prevotella copri increases fat accumulation in pigs fed with formula diets

C Chen, S Fang, H Wei, M He, H Fu, X Xiong, Y Zhou… - Microbiome, 2021 - Springer
Background Excessive fat accumulation of pigs is undesirable, as it severely affects
economic returns in the modern pig industry. Studies in humans and mice have examined …

Prevotella: A key player in ruminal metabolism

CL Betancur-Murillo, SB Aguilar-Marín, J Jovel - Microorganisms, 2022 - mdpi.com
Ruminants are foregut fermenters that have the remarkable ability of converting plant
polymers that are indigestible to humans into assimilable comestibles like meat and milk …

Microbiome epidemiology and association studies in human health

H VanEvery, EA Franzosa, LH Nguyen… - Nature Reviews …, 2023 - nature.com
Studies of the human microbiome share both technical and conceptual similarities with
genome-wide association studies and genetic epidemiology. However, the microbiome has …

Genomic diversity and ecology of human-associated Akkermansia species in the gut microbiome revealed by extensive metagenomic assembly

N Karcher, E Nigro, M Punčochář, A Blanco-Míguez… - Genome biology, 2021 - Springer
Background Akkermansia muciniphila is a human gut microbe with a key role in the
physiology of the intestinal mucus layer and reported associations with decreased body …

Genetic innovations in animal–microbe symbioses

J Perreau, NA Moran - Nature Reviews Genetics, 2022 - nature.com
Animal hosts have initiated myriad symbiotic associations with microorganisms and often
have maintained these symbioses for millions of years, spanning drastic changes in …

Dietary fiber intake, the gut microbiome, and chronic systemic inflammation in a cohort of adult men

W Ma, LH Nguyen, M Song, DD Wang, EA Franzosa… - Genome medicine, 2021 - Springer
Background A higher intake of dietary fiber is associated with a decreased risk of chronic
inflammatory diseases such as cardiovascular disease and inflammatory bowel disease …