High-resolution mapping of microvasculature has been applied to diverse body systems,
including the retinal and choroidal vasculature, cardiac vasculature, the central nervous …

The enhanced permeability and retention (EPR) effect has underlain the predominant
nanomedicine design philosophy for the past three decades. However, growing evidence …

Insufficient oxygenation (hypoxia), acidic pH (acidosis), and elevated levels of reactive
oxygen species (ROS), such as H2O2, are characteristic abnormalities of the tumor …

Non-invasive deep-tissue three-dimensional optical imaging of live mammals with high
spatiotemporal resolution is challenging owing to light scattering. We developed near …

Noninvasive optical imaging with deep tissue penetration depth and high spatiotemporal
resolution is important to longitudinally studying the biology at the single-cell level in live …

Innovation and progress in radiation oncology depend on discovery and insights realized
through research in radiation biology. Radiobiology research has led to fundamental …

Nanosurfaces have improved clinical osseointegration by increasing bone/implant contact.
Neovascularization is considered an essential prerequisite to osteogenesis, but no previous …

We demonstrate a method for differentiating tissue disease states using the intrinsic texture
properties of speckle in optical coherence tomography (OCT) images of normal and tumor …

Although endothelial cell apoptosis participates in the tumor shrinkage after single high-
dose radiotherapy, little is known regarding the vascular response after conventionally …

For translational cancer research, pre-clinical in-vivo studies using small animals have
become indispensable in bridging the gap between in-vitro cell experiments and clinical …