Pathogenesis of allergic diseases and implications for therapeutic interventions
J Wang, Y Zhou, H Zhang, L Hu, J Liu, L Wang… - Signal transduction and …, 2023 - nature.com
Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …
[HTML][HTML] NOD1 and NOD2: signaling, host defense, and inflammatory disease
The nucleotide-binding oligomerization domain (NOD) proteins NOD1 and NOD2, the
founding members of the intracellular NOD-like receptor family, sense conserved motifs in …
founding members of the intracellular NOD-like receptor family, sense conserved motifs in …
The genetics of asthma and the promise of genomics-guided drug target discovery
Asthma is an inflammatory airway disease that is estimated to affect 339 million people
globally. The symptoms of about 5–10% of patients with asthma are not adequately …
globally. The symptoms of about 5–10% of patients with asthma are not adequately …
NOD proteins: regulators of inflammation in health and disease
Entry of bacteria into host cells is an important virulence mechanism. Through peptidoglycan
recognition, the nucleotide-binding oligomerization domain (NOD) proteins NOD1 and …
recognition, the nucleotide-binding oligomerization domain (NOD) proteins NOD1 and …
Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets
V Mishra, J Banga, P Silveyra - Pharmacology & Therapeutics, 2018 - Elsevier
Asthma is a complex inflammatory disease characterized by airway inflammation and
hyperresponsiveness. The mechanisms associated with the development and progression …
hyperresponsiveness. The mechanisms associated with the development and progression …
Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance
Airway tolerance is the usual outcome of inhalation of harmless antigens. Although T cell
deletion and anergy are likely components of tolerogenic mechanisms in the lung …
deletion and anergy are likely components of tolerogenic mechanisms in the lung …
The biology of thymic stromal lymphopoietin (TSLP)
SF Ziegler, F Roan, BD Bell, TA Stoklasek… - Advances in …, 2013 - Elsevier
Originally shown to promote the growth and activation of B cells, thymic stromal
lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic …
lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic …
NOD1 and NOD2 signaling in infection and inflammation
LO Moreira, DS Zamboni - Frontiers in immunology, 2012 - frontiersin.org
Sensing intracellular pathogens is a process mediated by innate immune cells that is crucial
for the induction of inflammatory processes and effective adaptive immune responses …
for the induction of inflammatory processes and effective adaptive immune responses …
TSLP expression: cellular sources, triggers, and regulatory mechanisms
T Takai - Allergology International, 2012 - jstage.jst.go.jp
Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine initially identified in the culture
supernatant of a thymic stromal cell line. Highly expressed in the epidermis in skin lesions of …
supernatant of a thymic stromal cell line. Highly expressed in the epidermis in skin lesions of …
The importance of TSLP in allergic disease and its role as a potential therapeutic target
A Cianferoni, J Spergel - Expert review of clinical immunology, 2014 - Taylor & Francis
Thymic stromal lymphopoietin (TSLP) is an epithelial-derived cytokine similar to IL-7, whose
gene is located on chromosome 5q22. 1 and it exerts its biological function through the …
gene is located on chromosome 5q22. 1 and it exerts its biological function through the …