Management of pest insects and plant diseases by non-transformative RNAi

D Cagliari, NP Dias, DM Galdeano… - Frontiers in plant …, 2019 - frontiersin.org
Since the discovery of RNA interference (RNAi), scientists have made significant progress
towards the development of this unique technology for crop protection. The RNAi …

Ready for repair? Gene editing enters the clinic for the treatment of human disease

MPT Ernst, M Broeders, P Herrero-Hernandez… - … Therapy Methods & …, 2020 - cell.com
We present an overview of clinical trials involving gene editing using clustered interspaced
short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9), transcription …

Double-stranded RNA binding protein, Staufen, is required for the initiation of RNAi in coleopteran insects

JS Yoon, K Mogilicherla, D Gurusamy… - Proceedings of the …, 2018 - National Acad Sciences
RNA interference (RNAi) is being used to develop methods to control pests and disease
vectors. RNAi is robust and systemic in coleopteran insects but is quite variable in other …

lnc RNA s: novel players in intervertebral disc degeneration and osteoarthritis

WK Chen, XH Yu, W Yang, C Wang, WS He… - Cell …, 2017 - Wiley Online Library
The term long non‐coding RNA (lnc RNA) refers to a group of RNA s with length more than
200 nucleotides, limited protein‐coding potential, and having widespread biological …

RNA Interference of Four Genes in Adult Bactrocera dorsalis by Feeding Their dsRNAs

X Li, M Zhang, H Zhang - PloS one, 2011 - journals.plos.org
Background RNA interference (RNAi) is a powerful method to inhibit gene expression in a
sequence specific manner. Recently silencing the target gene through feeding has been …

Maintaining the silence: reflections on long-term RNAi

K Raemdonck, RE Vandenbroucke, J Demeester… - Drug discovery today, 2008 - Elsevier
Since the demonstration of RNA interference (RNAi) in mammalian cells, considerable
research and financial effort has gone towards implementing RNAi as a viable therapeutic …

RNAi-biofungicides: a quantum leap for tree fungal pathogen management

G Sellamuthu, A Chakraborty, RR Vetukuri… - Critical Reviews in …, 2024 - Taylor & Francis
Fungal diseases threaten the forest ecosystem, impacting tree health, productivity, and
biodiversity. Conventional approaches to combating diseases, such as biological control or …

RNAi-based therapy: combating shrimp viral diseases

MS Alam, MN Islam, M Das, SF Islam, MG Rabbane… - Viruses, 2023 - mdpi.com
Shrimp aquaculture has become a vital industry, meeting the growing global demand for
seafood. Shrimp viral diseases have posed significant challenges to the aquaculture …

Differential effects of RNAi treatments on field populations of the western corn rootworm

CC Chu, W Sun, JL Spencer, BR Pittendrigh… - Pesticide biochemistry …, 2014 - Elsevier
RNA interference (RNAi) mediated crop protection against insect pests is a technology that
is greatly anticipated by the academic and industrial pest control communities. Prior to …

RNAi as a treatment for HIV-1 infection

JJ Rossi - Biotechniques, 2006 - Taylor & Francis
Human immunodeficiency virus type 1 (HIV-1) was the first primate virus shown to be
inhibited by RNA interference (RNAi). Early studies used both synthetic and promoter …