Cytochrome P450s (CYPs) are the largest enzyme family involved in NADPH-and/or O2-
dependent hydroxylation reactions across all the domains of life. In plants and animals …

Alkaloids from plants are characterised by structural diversity and bioactivity, and maintain a
privileged position in both modern and traditional medicines. In recent years, there have …

Monoterpenoid indole alkaloids (MIAs) are among the most diverse specialized metabolites
in plants and are of great pharmaceutical importance. We leveraged single-cell …

Camptothecin and its derivatives are widely used for treating malignant tumors. Previous
studies revealed only a limited number of candidate genes for camptothecin biosynthesis in …

Cytochrome P450s (P450s) have been at the center of herbicide metabolism research as a
result of their ability to endow selectivity in crops and resistance in weeds. In the last 20 …

The (seco) iridoids and their derivatives, the monoterpenoid indole alkaloids (MIAs), form
two large families of plant-derived bioactive compounds with a wide spectrum of high-value …

Being by far the largest family of enzymes to support plant metabolism, the cytochrome
P450s (CYPs) constitute an excellent reporter of metabolism architecture and evolution. The …

Chemistry and biology of monoterpene indole alkaloid biosynthesis - Natural Product Reports
(RSC Publishing) DOI:10.1039/B512615K Royal Society of Chemistry View PDF …

The Catharanthus (or Vinca) alkaloids comprise a group of about 130 terpenoid indole
alkaloids. Vinblastine is now marketed for more than 40 years as an anticancer drug and …

The production of plant secondary metabolites by means of large-scale culture of plant cells
in bioreactors is technically feasible. The economy of such a production is the major …