Targeted treatment of solid tumors in pediatric precision oncology

I Bertacca, F Pegoraro, A Tondo, C Favre - Frontiers in Oncology, 2023 - frontiersin.org
The treatment of childhood solid cancer has markedly evolved in recent years following a
refined molecular characterization and the introduction of novel targeted drugs. On one …

Advancing presurgical non-invasive molecular subgroup prediction in medulloblastoma using artificial intelligence and MRI signatures

YRJ Wang, P Wang, Z Yan, Q Zhou, F Gunturkun, P Li… - Cancer Cell, 2024 - cell.com
Global investigation of medulloblastoma has been hindered by the widespread
inaccessibility of molecular subgroup testing and paucity of data. To bridge this gap, we …

MBMethPred: a computational framework for the accurate classification of childhood medulloblastoma subgroups using data integration and AI-based approaches

E Sharif Rahmani, A Lawarde, P Lingasamy… - Frontiers in …, 2023 - frontiersin.org
Childhood medulloblastoma is a malignant form of brain tumor that is widely classified into
four subgroups based on molecular and genetic characteristics. Accurate classification of …

[HTML][HTML] MBMethPred: a computational framework for the accurate classification of childhood medulloblastoma subgroups using data integration and AI-based …

ES Rahmani, A Lawarde, P Lingasamy… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
Childhood medulloblastoma is a malignant form of brain tumor that is widely classified into
four subgroups based on molecular and genetic characteristics. Accurate classification of …

Implementation of a High-Accuracy Targeted Gene Expression Panel for Clinical Care

AY Alontaga, P Cano, H Ozakinci, JA Puskas… - The Journal of Molecular …, 2024 - Elsevier
This study describes the validation of a clinical RNA expression panel with evaluation of
concordance between gene copy gain by a next-generation sequencing (NGS) assay and …

Kappa statistic considerations in evaluating inter-rater reliability between two raters: which, when and context matters

M Li, Q Gao, T Yu - BMC cancer, 2023 - Springer
Background In research designs that rely on observational ratings provided by two raters,
assessing inter-rater reliability (IRR) is a frequently required task. However, some studies fall …

[PDF][PDF] Edris Sharif Rahmani1, Ankita Lawarde1, 2, Prakash Lingasamy1, Sergio Vela Moreno1, 2, Andres Salumets1, 2, 3 and Vijayachitra Modhukur1, 2

M Mutarelli, Z Zhang, NQK Le, V Modhukur - 2023 - researchgate.net
Medulloblastoma (MB) is the most prevalent malignant form of brain tumor among children,
accounting for approximately 20% of all central nervous system (CNS) malignancies. The …