miRNAs as potential game-changers in bone diseases: Future medicinal and clinical Uses

AS Doghish, MS Elballal, O Elazazy… - … -Research and Practice, 2023 - Elsevier
Abstract MicroRNAs (miRNAs), short, highly conserved non-coding RNA, influence gene
expression by sequential mechanisms such as mRNA breakdown or translational …

The impact of microgravity on bone in humans

D Grimm, J Grosse, M Wehland, V Mann, JE Reseland… - Bone, 2016 - Elsevier
Experiencing real weightlessness in space is a dream for many of us who are interested in
space research. Although space traveling fascinates us, it can cause both short-term and …

The signaling pathways involved in chondrocyte differentiation and hypertrophic differentiation

J Li, S Dong - Stem cells international, 2016 - Wiley Online Library
Chondrocytes communicate with each other mainly via diffusible signals rather than direct
cell‐to‐cell contact. The chondrogenic differentiation of mesenchymal stem cells (MSCs) is …

[HTML][HTML] MicroRNA-221 is involved in the regulation of osteoporosis through regulates RUNX2 protein expression and osteoblast differentiation

Y Zhang, Y Gao, L Cai, F Li, Y Lou, N Xu… - American journal of …, 2017 - ncbi.nlm.nih.gov
Introduction: MicroRNAs (miRNAs) has emerged as important factors in osteogenesis and
chondrogenesis. This study aimed to determine whether miR-221 is involved in the …

Long noncoding RNA MALAT1 promotes osterix expression to regulate osteogenic differentiation by targeting miRNA‐143 in human bone marrow‐derived …

Y Gao, F Xiao, C Wang, C Wang, P Cui… - Journal of Cellular …, 2018 - Wiley Online Library
Osteogenic differentiation of human bone marrow‐derived mesenchymal stem cells
(hBMSCs) is essential for the human bone formation, and emerging evidence shows that …

DC‐STAMP: a key regulator in osteoclast differentiation

YH Chiu, CT Ritchlin - Journal of cellular physiology, 2016 - Wiley Online Library
Osteoimmunology research is a new emerging research field that investigates the links
between the bone and immune responses. Results from osteoimmunology studies suggest …

Micrornas at the interface between osteogenesis and angiogenesis as targets for bone regeneration

LF Fröhlich - Cells, 2019 - mdpi.com
Bone formation and regeneration is a multistep complex process crucially determined by the
formation of blood vessels in the growth plate region. This is preceded by the expression of …

Circulating miRNAs in bone health and disease

J Grillari, RE Mäkitie, R Kocijan, J Haschka… - Bone, 2021 - Elsevier
Abstract microRNAs have evolved as important regulators of multiple biological pathways
essential for bone homeostasis, and microRNA research has furthered our understanding of …

The emerging role of MicroRNAs in bone diseases and their therapeutic potential

LA Bravo Vázquez, MY Moreno Becerril… - Molecules, 2021 - mdpi.com
MicroRNAs (miRNAs) are a class of small (20–24 nucleotides), highly conserved, non-
coding RNA molecules whose main function is the post-transcriptional regulation of gene …

MicroRNAs in osteoclastogenesis and function: potential therapeutic targets for osteoporosis

X Ji, X Chen, X Yu - International journal of molecular sciences, 2016 - mdpi.com
Abnormal osteoclast formation and resorption play a fundamental role in osteoporosis
pathogenesis. Over the past two decades, much progress has been made to target …