Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a conserved
protein kinase that plays essential roles in various biological processes. It is located in the …

Down's syndrome is the most common genetic cause of learning difficulties, and individuals
with this condition represent the largest group of people with dementia under the age of 50 …

In this article, we first present a summary of the general assumptions about Down syndrome
(DS) still to be found in the literature. We go on to show how new research has modified …

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …

Protein kinases (PKs) have been recognized as central nervous system (CNS)-disease-
relevant targets due to their master regulatory role in different signal transduction cascades …

Harmine is isolated from the seeds of the medicinal plant, Peganum harmala L., and has
been used for thousands of years in the Middle East and China. Harmine has many …

DYRK1A is a serine/threonine kinase encoded on human chromosome 21 (HSA21) that has
been implicated in several pathologies of Down syndrome (DS), including cognitive deficits …

Down syndrome (DS) is one of the leading causes of intellectual disability, and patients with
DS face various health issues, including learning and memory deficits, congenital heart …

Oximes have been studied for decades because of their significant roles as
acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have …

Perfectly orchestrated periodic gene expression during cell cycle progression is essential for
maintaining genome integrity and ensuring that cell proliferation can be stopped by …