A review of traditional Chinese medicine on treatment of diabetic nephropathy and the involved mechanisms

XJ Liu, XK Hu, H Yang, LM Gui, ZX Cai… - The American journal …, 2022 - World Scientific
Diabetic nephropathy (DN) is a common microvascular complication of diabetes mellitus
(DM), which can lead to renal failure in diabetic patients. At present, the first-line drugs for …

Autophagy and its therapeutic potential in diabetic nephropathy

YP Han, LJ Liu, JL Yan, MY Chen, XF Meng… - Frontiers in …, 2023 - frontiersin.org
Diabetic nephropathy (DN), the leading cause of end-stage renal disease, is the most
significant microvascular complication of diabetes and poses a severe public health concern …

Down-regulation of Risa improves podocyte injury by enhancing autophagy in diabetic nephropathy

PP Su, DW Liu, SJ Zhou, H Chen, XM Wu… - Military Medical …, 2022 - Springer
Background LncRNA AK044604 (regulator of insulin sensitivity and autophagy, Risa) and
autophagy-related factors Sirt1 and GSK3β play important roles in diabetic nephropathy …

Chinese herbal medicine and its active compounds in attenuating renal injury via regulating autophagy in diabetic kidney disease

P Liu, W Zhu, Y Wang, G Ma, H Zhao… - Frontiers in Endocrinology, 2023 - frontiersin.org
Diabetic kidney disease (DKD) is the main cause of end-stage renal disease worldwide, and
there is a lack of effective treatment strategies. Autophagy is a highly conserved lysosomal …

[HTML][HTML] Therapeutic application of traditional chinese medicine in kidney disease: Sirtuins as potential targets

Q Jin, T Liu, F Ma, L Yang, H Mao, Y Wang, P Li… - Biomedicine & …, 2023 - Elsevier
Sirtuins are a family of NAD+ III-dependent histone deacetylases that consists of seven
family members, Sirt1-Sirt7, which regulate various signalling pathways and are involved in …

Network pharmacology study of Yishen capsules in the treatment of diabetic nephropathy

J Fang, C Wang, J Zheng, Y Liu - Plos one, 2022 - journals.plos.org
Objective In this study, we used network pharmacology to explore the possible therapeutic
mechanism underlying the treatment of diabetic nephropathy with Yishen capsules. Methods …

Potential molecular mechanism of yishen capsule in the treatment of diabetic nephropathy based on network pharmacology and molecular docking

Y Hu, S Liu, W Liu, Z Zhang, Y Liu, S Li… - … and Obesity: Targets …, 2022 - Taylor & Francis
Purpose Using network pharmacology and molecular docking to explore the mechanism of
Yishen Capsule in the treatment of diabetic nephropathy. Materials and Methods Active …

Icariin activates autophagy to trigger TGFβ1 upregulation and promote angiogenesis in EA. hy926 human vascular endothelial cells

X Li, Y Wen, L Sheng, R Guo, Y Zhang, L Shao - Bioengineered, 2022 - Taylor & Francis
Angiogenesis plays an important role in tissue development and repair, and how to regulate
angiogenesis effectively is a widely studied problem in the biomedical field. In recent years …

Integrative analyses of biomarkers and pathways for diabetic nephropathy

B Li, X Zhao, W Xie, Z Hong, Y Zhang - Frontiers in Genetics, 2023 - frontiersin.org
Background: Diabetic nephropathy (DN) is a widespread diabetic complication and a major
cause of terminal kidney disease. There is no doubt that DN is a chronic disease that …

Protective effect of keluoxin against diabetic nephropathy in type 2 diabetic mellitus models

X Yang, X Han, Q Wen, X Qiu, H Deng… - Evidence‐Based …, 2021 - Wiley Online Library
Diabetic nephropathy (DN) is a chronic kidney disease that develops in patients with
diabetes mellitus (DM). Renal dysfunction and persistent proteinuria are the main clinical …