Publisher Summary This chapter focuses on interleukin-8 (IL-8) and related chemotactic
cytokines—namely, CXC and CC chemokines. IL-8 is the best known member of a new …

The aggressive nature of metastatic human cancer has been shown to be related to
numerous abnormalities in growth factors and their receptors. These perturbations confer a …

IL-8, a member of the chemokine family, has been shown to play an important role in tumor
growth, angiogenesis, and metastasis. The objective of this study was to determine the …

Chemokines play a paramount role in the tumor progression. Chronic inflammation
promotes tumor formation. Both tumor cells and stromal cells elaborate chemokines and …

Chemokines represent a large family of polypeptide signaling molecules that are notable for
their role in chemotaxis, leukocyte homing, directional migration, and G protein coupled …

Normal melanocytes require a number of exogenous growth factors in contrast to most
metastatic malignant melanomas. This investigation demonstrates that endogenously …

Vascular endothelial growth factor (VEGF) has been shown to be a potent mediator of
angiogenesis that functions as a survival factor for endothelial cells by up-regulating Bcl-2 …

Abstract Purpose: Interferon (IFN)-α2b is the only Food and Drug Administration–approved
treatment for operable high-risk melanoma that has been shown to significantly and durably …

Human tumors can constitutively express cytokines and growth factors, but the extent of this
expression has not been investigated. Using 44 different probes to cytokines, growth factors …

Growth and progression of malignant melanoma cells is influenced by a complex network of
growth-stimulating and-inhibiting factors produced by both the tumor cells and the local …