In addition to physical barriers, neutrophils are considered a part of the first line of immune
defense. They can be found in the bloodstream, with a lifespan of 6–8 h, and in tissue …

An animal model to study human infectious diseases should accurately reproduce the
various aspects of disease. Domestic pigs (Sus scrofa domesticus) are closely related to …

Tuberculosis (TB) lesions are extremely complex and dynamic. Here, we review the multiple
types and fates of pulmonary lesions that form following infection by M ycobacterium …

Great progress has been made over the past half-century, but TB remains a formidable
global health problem, particularly in low-and middle-income countries. Understanding the …

Animal tuberculosis (TB) is a multi-host disease caused by members of the Mycobacterium
tuberculosis complex (MTC). Due to its impact on economy, sanitary standards of milk and …

Granulomas are the hallmark of Mycobacterium tuberculosis (M. tb) infection and thus sit at
the center of tuberculosis (TB) immunopathogenesis. TB can result from either early …

La evolución entre la infección por Mycobacterium tuberculosis y la tuberculosis activa es
multifactorial e implica diferentes escalas biológicas. La síntesis de ESAT-6 o la inducción …

Bovine tuberculosis (bTB) is a chronic granulomatous caseous-necrotising inflammatory
process that mainly affects the lungs and their draining lymph nodes (Ln.). The pathological …

In drug development, there are typically a series of preclinical studies that must be
completed with new compounds or regimens before use in humans. A sequence of in vitro …

A key aspect of TB pathogenesis that maintains Mycobacterium tuberculosis in the human
population is the ability to cause necrosis in pulmonary lesions. As co-evolution shaped M …