New neurons and glial cells are generated in an extensive germinal niche adjacent to the
walls of the lateral ventricles in the adult brain. The primary progenitors (B1 cells) have …

Neurogenesis persists in two germinal regions in the adult mammalian brain, the
subventricular zone of the lateral ventricles and the subgranular zone in the hippocampal …

Neural stem cells (NSCs, B1 cells) are retained in the walls of the adult lateral ventricles but,
unlike embryonic NSCs, are displaced from the ventricular zone (VZ) into the subventricular …

Major developments in the neural stem cell (NSC) field in recent years provide new insights
into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on …

Oxygen (O2) is a substrate for energy production in the cell and is a rapid regulator of
cellular metabolism. Recent studies have also implicated O2 and its signal transduction …

In the mammalian brain, neurogenesis continues only in few regions of the forebrain. The
molecular signals governing neurogenesis in these unique neurogenic niches, however, are …

Highlights•Glial cells are central components of all neurogenic niches.•Certain glial cells act
as neural stem cells while others regulate neural stem cells.•A subset of embryonic radial …

Adult neurogenesis in the subventricular zone is a topic of intense research, since it has vast
implications for the fundamental understanding of the neurobiology of the brain and its …

Adult neurogenesis is an exceptional feature of the adult brain and in an intriguing way
bridges between neuronal and glial neurobiology. Essentially, all classes of glial cells are …

Glial cells are an essential component of the nervous system of vertebrates and
invertebrates. In the human brain, glia are as numerous as neurons, yet the importance of …