The thymus is a crucial organ for the development of T cells. T cell progenitors first migrate
from the bone marrow into the thymus. During the journey to become a mature T cell …

Abstract Development of immunocompetent T cells in the thymus is required for effective
defence against all types of pathogens, including viruses, bacteria and fungi. To this end, T …

The inevitability of evolution of the adaptive immune system with its mechanism of randomly
rearranging segments of the T cell receptor (TCR) gene is the generation of self-reactive …

Thymic stromal cells (TSCs) are critical regulators of T cell tolerance, but their basic biology
has remained under-characterized because they are relatively rare and difficult to isolate …

The thymus is a unique primary lymphoid organ that supports the production of self‐tolerant
T‐cells essential for adaptive immunity. Intrathymic microenvironments are …

The thymus plays a pivotal role in generating a highly-diverse repertoire of T lymphocytes
while preventing autoimmunity. Thymus seeding progenitors (TSPs) are a heterogeneous …

Dendritic cells (DCs) are essential for establishing central tolerance in the thymus; however,
mechanisms supporting their homeostasis and activation remain unresolved. Through …

The thymus is a unique primary lymphoid organ that supports the production of self-tolerant
T-cells essential for adaptive immunity. Intrathymic microenvironments are …

The intestinal immune system is constantly faced with a vast variety of foreign antigens from
food and commensal microbiota on top of intestinal self-antigens. To prevent pathology, the …

Czech Young Immunologists: Bound by Science, United in Purpose Page 1 Received: MONTH
DD, YYY; Revised: MONTH DD, YYY; Accepted: MONTH DD, YYY This article has been accepted …