Induced pluripotent stem cell (iPSC) technology has emerged as an important tool in
understanding, and potentially reversing, disease pathology. This is particularly true in the …

The establishment of a reliable model for the study of Purkinje cells in vitro is of particular
importance, given their central role in cerebellar function and pathology. Recent advances in …

The cerebellum plays a critical role in all vertebrates, and many neurological disorders are
associated with cerebellum dysfunction. A major limitation in cerebellar research has been …

The cerebellar ataxias are a group of incurable brain disorders that are caused primarily by
the progressive dysfunction and degeneration of cerebellar Purkinje cells. The lack of …

The main purpose of this chapter is to introduce the reader to the complexity of nervous
system development, to better understand the huge challenge to faithfully reproduce this …