The significance of the placental genome and methylome in fetal and maternal health
GF Del Gobbo, C Konwar, WP Robinson - Human genetics, 2020 - Springer
The placenta is a crucial organ for supporting a healthy pregnancy, and defective
development or function of the placenta is implicated in a number of complications of …
development or function of the placenta is implicated in a number of complications of …
Association between maternal diet, smoking, and the placenta MTHFR 677C/T genotype and global placental DNA methylation
Introduction The placenta provides nutrients to the fetus, and it has protective effects against
harmful substances. Unhealthy maternal diets and toxic agents might increase free radical …
harmful substances. Unhealthy maternal diets and toxic agents might increase free radical …
Accurate ethnicity prediction from placental DNA methylation data
Background The influence of genetics on variation in DNA methylation (DNAme) is well
documented. Yet confounding from population stratification is often unaccounted for in …
documented. Yet confounding from population stratification is often unaccounted for in …
The application of epiphenotyping approaches to DNA methylation array studies of the human placenta
Background Genome-wide DNA methylation (DNAme) profiling of the placenta with Illumina
Infinium Methylation bead arrays is often used to explore the connections between in utero …
Infinium Methylation bead arrays is often used to explore the connections between in utero …
DNA methylation profiling of acute chorioamnionitis-associated placentas and fetal membranes: insights into epigenetic variation in spontaneous preterm births
Background Placental inflammation, often presenting as acute chorioamnionitis (aCA), is
commonly associated with preterm birth. Preterm birth can have both immediate and long …
commonly associated with preterm birth. Preterm birth can have both immediate and long …
Genomic imbalances in the placenta are associated with poor fetal growth
GF Del Gobbo, Y Yin, S Choufani, EA Butcher, J Wei… - Molecular …, 2021 - Springer
Background Fetal growth restriction (FGR) is associated with increased risks for
complications before, during, and after birth, in addition to risk of disease through to …
complications before, during, and after birth, in addition to risk of disease through to …
The proper diagnosis of thrombophilic status in preventing fetal growth restriction
BM Mihai, T Salmen, AM Cioca, RE Bohîlțea - Diagnostics, 2023 - mdpi.com
Fetal growth restriction is an important part of monitoring a pregnancy. Because guidelines
or diagnostic criteria for either minor or major thrombophilia are scarce, this systematic …
or diagnostic criteria for either minor or major thrombophilia are scarce, this systematic …
No Association Between ADIPOQ or MTHFR Polymorphisms and Gestational Diabetes Mellitus in South African Women
Purpose Gestational diabetes mellitus (GDM) is a growing public health concern. GDM
affects approximately 14% of pregnancies globally, and without effective treatment, is …
affects approximately 14% of pregnancies globally, and without effective treatment, is …
Decreased global DNA hydroxymethylation in neural tube defects: association with polycyclic aromatic hydrocarbons
Hydroxymethylcytosine (5hmC), a distinct epigenetic marker that plays a role in DNA active
demethylation, has been reported to be important for embryonic development and may …
demethylation, has been reported to be important for embryonic development and may …
Association of a placental Interleukin-6 genetic variant (rs1800796) with DNA methylation, gene expression and risk of acute chorioamnionitis
Background Acute chorioamnionitis (aCA), inflammation of the placenta and fetal
membranes, is a frequently reported lesion in preterm deliveries. Genetic variants in innate …
membranes, is a frequently reported lesion in preterm deliveries. Genetic variants in innate …