Excessive gluconeogenesis causes the hepatic insulin resistance paradox and its sequelae
AN Onyango - Heliyon, 2022 - cell.com
Background Hepatic insulin signaling suppresses gluconeogenesis but promotes de novo
lipid synthesis. Paradoxically, hepatic insulin resistance (HIR) enhances both …
lipid synthesis. Paradoxically, hepatic insulin resistance (HIR) enhances both …
Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress
KA O'Brien, BD McNally, AP Sowton, A Murgia… - BMC biology, 2021 - Springer
Background Tissue hypoxia is a key feature of several endemic hepatic diseases, including
alcoholic and non-alcoholic fatty liver disease, and organ failure. Hypoxia imposes a severe …
alcoholic and non-alcoholic fatty liver disease, and organ failure. Hypoxia imposes a severe …
[PDF][PDF] The role of diet and gut microbiota in lipid metabolism: Implications for health outcomes using a mouse model
I Ampong - 2020 - openresearch.surrey.ac.uk
The prevalence of non-Alcoholic Fatty Liver Disease (NAFLD) has now reached epidemic
proportions, but the role of gene-lifestyle interactions in its pathogenesis remains poorly …
proportions, but the role of gene-lifestyle interactions in its pathogenesis remains poorly …