Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …

The increasing epidemic of obesity worldwide is linked to serious health effects, including
increased prevalence of type 2 diabetes mellitus, cardiovascular disease and nonalcoholic …

Reactive oxygen species (ROS) are well known for their role in mediating both physiological
and pathophysiological signal transduction. Enzymes and subcellular compartments that …

This article presents a personal and critical review of the history of the malate–aspartate
shuttle (MAS), starting in 1962 and ending in 2020. The MAS was initially proposed as a …

Oxidative stress is mainly caused by intracellular reactive oxygen species (ROS) production,
which is highly associated with normal physiological homeostasis and the pathogenesis of …

Over the past decades, peroxisomes have emerged as key regulators in overall cellular lipid
and reactive oxygen species metabolism. In mammals, these organelles have also been …

Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …

The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These
transcription factors control the expression of a battery of genes involved in the uptake …

The liver metabolizes ethanol through three enzymatic pathways: alcohol dehydrogenase
(ADH), cytochrome p450 (also called MEOS), and catalase. Alcohol dehydrogenase class I …

Peroxisomes are dynamic organelles that play an essential role in a variety of cellular
catabolic and anabolic metabolic pathways, including fatty acid alpha-and beta-oxidation …