Biomolecular condensates regulate transcription by dynamically compartmentalizing the
transcription machinery. Classic models of transcription regulation focus on the recruitment …

Biomolecular condensates are thought to create subcellular microenvironments that
regulate specific biochemical activities. Extensive in vitro work has helped link condensate …

Long noncoding (lnc) RNAs emerge as regulators of genome stability. The nuclear-enriched
abundant transcript 1 (NEAT1) is overexpressed in many tumors and is responsive to …

Abstract Eukaryotic RNA polymerase II (RNAPII) is responsible for the transcription of the
protein-coding genes in the cell. Enormous progress has been made in discovering the …

Liquid–liquid phase separation (LLPS), an emerging biophysical phenomenon, can
sequester molecules to implement physiological and pathological functions. LLPS …

O-Linked β-N-acetylglucosamine (O-GlcNAc) is an essential, dynamic monosaccharide post-
translational modification (PTM) found on serine and threonine residues of thousands of …

MYC family oncoproteins regulate the expression of a large number of genes and broadly
stimulate elongation by RNA polymerase II (RNAPII). While the factors that control the …

RNA-binding proteins are frequently deregulated in cancer and emerge as effectors of the
DNA damage response (DDR). The non-POU domain–containing octamer-binding protein …

In cells, transcription is tightly regulated on multiple layers. The condensation of the
transcription machinery into distinct phases is hypothesised to spatio-temporally fine tune …

Transcription competes with other DNA-dependent processes, such as DNA repair, for
access to its substrate, DNA. However, the principles governing the interplay between these …