Regulatory T cell dysfunction in type 1 diabetes: what's broken and how can we fix it?
CM Hull, M Peakman, TIM Tree - Diabetologia, 2017 - Springer
Type 1 diabetes is an autoimmune disease characterised by the destruction of insulin
producing beta cells in the pancreas. Whilst it remains unclear what the original triggering …
producing beta cells in the pancreas. Whilst it remains unclear what the original triggering …
Retrospective and perspective of plant epigenetics in China
Epigenetics refers to the study of heritable changes in gene function that do not involve
changes in the DNA sequence. Such effects on cellular and physiological phenotypic traits …
changes in the DNA sequence. Such effects on cellular and physiological phenotypic traits …
ATX3, ATX4, and ATX5 Encode Putative H3K4 Methyltransferases and Are Critical for Plant Development
Methylation of Lys residues in the tail of the H3 histone is a key regulator of chromatin state
and gene expression, conferred by a large family of enzymes containing an evolutionarily …
and gene expression, conferred by a large family of enzymes containing an evolutionarily …
Altered chromatin compaction and histone methylation drive non-additive gene expression in an interspecific Arabidopsis hybrid
Background The merging of two diverged genomes can result in hybrid offspring that
phenotypically differ greatly from both parents. In plants, interspecific hybridization plays …
phenotypically differ greatly from both parents. In plants, interspecific hybridization plays …
Genome‐wide occupancy of histone H3K27 methyltransferases CURLY LEAF and SWINGER in Arabidopsis seedlings
Abstract The Polycomb Group (PcG) proteins form two protein complexes, PcG Repressive
Complex 1 (PRC 1) and PRC 2, which are key epigenetic regulators in eukaryotes. PRC 2 …
Complex 1 (PRC 1) and PRC 2, which are key epigenetic regulators in eukaryotes. PRC 2 …
DNA methylation repatterning accompanying hybridization, whole genome doubling and homoeolog exchange in nascent segmental rice allotetraploids
Allopolyploidization, which entails interspecific hybridization and whole genome duplication
(WGD), is associated with emergent genetic and epigenetic instabilities that are thought to …
(WGD), is associated with emergent genetic and epigenetic instabilities that are thought to …
The role of transcriptional regulation in hybrid vigor
R Botet, JJB Keurentjes - Frontiers in Plant Science, 2020 - frontiersin.org
The genetic basis of hybrid vigor in plants remains largely unsolved but strong evidence
suggests that variation in transcriptional regulation can explain many aspects of this …
suggests that variation in transcriptional regulation can explain many aspects of this …
CURLY LEAF regulates microRNA activity by controlling ARGONAUTE 1 degradation in plants
Abstract CURLY LEAF (CLF) encodes the methyltransferase subunit of the Polycomb
Repressor Complex 2 (PRC2), which regulates the expression of target genes through …
Repressor Complex 2 (PRC2), which regulates the expression of target genes through …
Transcriptome-Wide Analysis of RNA m6A Methylation and Gene Expression Changes Among Two Arabidopsis Ecotypes and Their Reciprocal Hybrids
Z Xu, X Shi, M Bao, X Song, Y Zhang, H Wang… - Frontiers in Plant …, 2021 - frontiersin.org
The remodeling of transcriptome, epigenome, proteome, and metabolome in hybrids plays
an important role in heterosis. N (6)-methyladenosine (m6A) methylation is the most …
an important role in heterosis. N (6)-methyladenosine (m6A) methylation is the most …
Cis‐regulated alternative splicing divergence and its potential contribution to environmental responses in Arabidopsis
X Wang, M Yang, D Ren, W Terzaghi… - The Plant …, 2019 - Wiley Online Library
Alternative splicing (AS) plays key roles in plant development and the responses of plants to
environmental changes. However, the mechanisms underlying AS divergence (differential …
environmental changes. However, the mechanisms underlying AS divergence (differential …