The environmental and metabolic pressures in the tumor microenvironment (TME) play a
key role in molding tumor development by impacting the stromal and immune cell fractions …

Despite an increasing arsenal of anticancer therapies, many patients continue to have poor
outcomes due to the therapeutic failures and tumor relapses. Indeed, the clinical efficacy of …

The effective treatment of advanced cervical cancer remains challenging. Herein, single‐
nucleus RNA sequencing (snRNA‐seq) and SpaTial enhanced resolution omics …

Hypoxia is a condition commonly observed in the core of solid tumors. The hypoxia-
inducible factors (HIF) act as hypoxia sensors that orchestrate a coordinated response …

Pancreatic islets are endocrine organs that depend on their microvasculature to function.
Along with endothelial cells, pericytes comprise the islet microvascular network. These …

Cancer is a leading cause of death worldwide. As a common characteristic of cancer,
hypoxia is associated with poor prognosis due to enhanced tumor malignancy and …

Extensive peritoneal spread and capacity for distant metastasis account for the majority of
mortality from epithelial ovarian cancer (EOC). Accumulating evidence shows that …

Cancer patients often receive a combination of antibodies targeting programmed death-
ligand 1 (PD-L1) and cytotoxic T lymphocyte antigen-4 (CTLA4). We conducted a window-of …

Background: Generally, hepatocellular carcinoma (HCC) exists in an immunosuppressive
microenvironment that promotes tumor evasion. Hypoxia can impact intercellular crosstalk in …

Background: Colorectal cancer (CRC) is one of the most common gastrointestinal tumors,
ranking in the top 5 of all common tumors in terms of incidence and mortality. However, the …