Efavirenz: history, development and future

B Costa, N Vale - Biomolecules, 2022 - mdpi.com
Efavirenz (Sustiva®) is a first-generation non-nucleoside reverse transcriptase inhibitor
(NNRTI) used to treat human immunodeficiency virus (HIV) type 1 infection or to prevent the …

Challenges and Opportunities for Consideration of Efavirenz Drug Repurposing for Alzheimer's Disease Therapeutics

B Boyarko, S Podvin, B Greenberg… - ACS Pharmacology & …, 2024 - ACS Publications
Therapeutic research and development for Alzheimer's disease (AD) has been an area of
intense research to alleviate memory loss and neurodegeneration. There is growing interest …

Drug reformulations and repositioning in pharmaceutical industry and its impact on market access: reassessment of nomenclature

S Murteira, Z Ghezaiel, S Karray… - Journal of Market Access …, 2013 - Taylor & Francis
Background: Medicinal products that have been developed and approved for one disease
may be the object of additional clinical development in other disease areas or of additional …

4-Aminoquinoline-hybridization en route towards the development of rationally designed antimalarial agents

R Raj, KM Land, V Kumar - RSC advances, 2015 - pubs.rsc.org
The resistance of Plasmodium falciparum, the causative agent of malaria, against quinine
and chloroquine along with the lack of malaria vaccines has encouraged the development of …

Interfirm bundling and vertical product differentiation

D Brito, H Vasconcelos - The Scandinavian Journal of …, 2015 - Wiley Online Library
In this paper, we study the competitive effects of bundled discounts offered by pairs of
independent firms. In a setting with vertically differentiated goods, where firms decide …

Fumaric acid microenvironment tablet formulation and process development for crystalline cenicriviroc mesylate, a BCS IV compound

MM Menning, SM Dalziel - Molecular pharmaceutics, 2013 - ACS Publications
Cenicriviroc mesylate (CVC) is a potent dual antagonist of CC chemokine receptor type 5
(CCR5) and CC chemokine receptor type 2 (CCR2) in phase 2b development as an entry …

Simplification of HAART therapy on ambulatory HIV patients in Malaysia: a randomized controlled trial

T Velvanathan, F Islahudin, BL Sim… - Pharmacy Practice …, 2016 - SciELO Espana
Resumen VELVANATHAN, Tineshwaran; ISLAHUDIN, Farida; SIM, Benedict L. y TAHA, Nur
A.. Simplification of HAART therapy on ambulatory HIV patients in Malaysia: a randomized …

[HTML][HTML] Highly active antiretroviral therapy dysregulates proliferation and differentiation of human pre-adipocytes

E Jones, P Mazirka, MA McNurlan, F Darras… - World journal of …, 2017 - ncbi.nlm.nih.gov
AIM To investigate the mechanism (s) by which potential effects of multi-drug highly-active
antiretroviral therapy contributes to lipodystrophy syndrome. METHODS Preadipocytes from …

A rational approach to identifying effective combined anticoronaviral therapies against feline coronavirus

SE Cook, H Vogel, D Castillo, M Olsen, N Pedersen… - bioRxiv, 2020 - biorxiv.org
Feline infectious peritonitis (FIP), caused by a genetic mutant of feline enteric coronavirus
known as FIPV, is a highly fatal disease of cats with no currently available vaccine or FDA …

Acute trigeminal neuralgia associated with initiation of emtricitabine/tenofovir for HIV pre-exposure prophylaxis

L Van Slyke, M Scott - … Association of Providers of AIDS Care …, 2018 - journals.sagepub.com
HIV pre-exposure prophylaxis (PrEP) with emtricitabine (FTC) and tenofovir disoproxil
fumarate (TDF) fixed-dose combination (FTC/TDF) is undergoing rapid scale-up in the …