Methyl-CpG-binding domain proteins: readers of the epigenome
How DNA methylation is interpreted and influences genome regulation remains largely
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …
FOXA1 O-GlcNAcylation–mediated transcriptional switch governs metastasis capacity in breast cancer
Y Liu, K Yu, X Kong, K Zhang, L Wang, N Zhang… - Science …, 2023 - science.org
FOXA1, a transcription factor involved in epigenetic reprogramming, is crucial for breast
cancer progression. However, the mechanisms by which FOXA1 achieves its oncogenic …
cancer progression. However, the mechanisms by which FOXA1 achieves its oncogenic …
[HTML][HTML] GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler
Background Transcription factor-dependent cellular reprogramming is integral to normal
development and is central to production of induced pluripotent stem cells. This process …
development and is central to production of induced pluripotent stem cells. This process …
[HTML][HTML] Dissecting the roles of MBD2 isoforms and domains in regulating NuRD complex function during cellular differentiation
N Schmolka, ID Karemaker, R Cardoso da Silva… - Nature …, 2023 - nature.com
Abstract The Nucleosome Remodeling and Deacetylation (NuRD) complex is a crucial
regulator of cellular differentiation. Two members of the Methyl-CpG-binding domain (MBD) …
regulator of cellular differentiation. Two members of the Methyl-CpG-binding domain (MBD) …
[HTML][HTML] The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II
S Osman, E Mohammad, M Lidschreiber… - Journal of Biological …, 2021 - ASBMB
The Cdk8 kinase module (CKM) is a dissociable part of the coactivator complex mediator,
which regulates gene transcription by RNA polymerase II. The CKM has both negative and …
which regulates gene transcription by RNA polymerase II. The CKM has both negative and …
[HTML][HTML] DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance
F D'anna, L Van Dyck, J Xiong, H Zhao, RV Berrens… - Genome biology, 2020 - Springer
Background Hypoxia is pervasive in cancer and other diseases. Cells sense and adapt to
hypoxia by activating hypoxia-inducible transcription factors (HIFs), but it is still an …
hypoxia by activating hypoxia-inducible transcription factors (HIFs), but it is still an …
[HTML][HTML] Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes
The genome-wide DNA methylation profile, or DNA methylome, is a critical component of the
overall epigenomic landscape that modulates gene activities and cell fate. Single-cell DNA …
overall epigenomic landscape that modulates gene activities and cell fate. Single-cell DNA …
[HTML][HTML] Emerging molecular and biological functions of MBD2, a reader of DNA methylation
KH Wood, Z Zhou - Frontiers in genetics, 2016 - frontiersin.org
DNA methylation is an epigenetic mark that is essential for many biological processes and is
linked to diseases such as cancer. Methylation is usually associated with transcriptional …
linked to diseases such as cancer. Methylation is usually associated with transcriptional …
Readers of DNA methylation, the MBD family as potential therapeutic targets
GD Ginder, DC Williams Jr - Pharmacology & Therapeutics, 2018 - Elsevier
DNA methylation represents a fundamental epigenetic modification that regulates chromatin
architecture and gene transcription. Many diseases, including cancer, show aberrant …
architecture and gene transcription. Many diseases, including cancer, show aberrant …