Genetic alphabet expansion technology by creating unnatural base pairs
Recent advancements in the creation of artificial extra base pairs (unnatural base pairs,
UBPs) are opening the door to a new research area, xenobiology, and genetic alphabet …
UBPs) are opening the door to a new research area, xenobiology, and genetic alphabet …
Conformational changes of non-B DNA
J Choi, T Majima - Chemical Society Reviews, 2011 - pubs.rsc.org
In contrast to B-DNA that has a right-handed double helical structure with Watson–Crick
base pairing under the ordinary physiological conditions, repetitive DNA sequences under …
base pairing under the ordinary physiological conditions, repetitive DNA sequences under …
Development of force field parameters for the simulation of single-and double-stranded DNA molecules and DNA–protein complexes
Although molecular dynamics (MD) simulations have been used extensively to study the
structural dynamics of proteins, the role of MD simulation in studies of nucleic acid based …
structural dynamics of proteins, the role of MD simulation in studies of nucleic acid based …
Factors contributing to aromatic stacking in water: evaluation in the context of DNA
KM Guckian, BA Schweitzer, RXF Ren… - Journal of the …, 2000 - ACS Publications
We report the use of thermodynamic measurements in a self-complementary DNA duplex (5
'-dXCGCGCG) 2, where X is an unpaired natural or nonnatural deoxynucleoside, to study …
'-dXCGCGCG) 2, where X is an unpaired natural or nonnatural deoxynucleoside, to study …
High-affinity DNA aptamer generation targeting von Willebrand factor A1-domain by genetic alphabet expansion for systematic evolution of ligands by exponential …
The novel evolutionary engineering method ExSELEX (genetic alphabet expansion for
systematic evolution of ligands by exponential enrichment) provides high-affinity DNA …
systematic evolution of ligands by exponential enrichment) provides high-affinity DNA …
High-affinity five/six-letter DNA aptamers with superior specificity enabling the detection of dengue NS1 protein variants beyond the serotype identification
Genetic alphabet expansion of DNA by introducing unnatural bases (UBs), as a fifth letter,
dramatically augments the affinities of DNA aptamers that bind to target proteins. To …
dramatically augments the affinities of DNA aptamers that bind to target proteins. To …
Showcasing Different G-Quadruplex Folds of a G-Rich Sequence: Between Rule-Based Prediction and Butterfly Effect
YM Vianney, N Schröder, J Jana… - Journal of the …, 2023 - ACS Publications
In better understanding the interactions of G-quadruplexes in a cellular or noncellular
environment, a reliable sequence-based prediction of their three-dimensional fold would be …
environment, a reliable sequence-based prediction of their three-dimensional fold would be …
The 8-17 DNAzyme can operate in a single active structure regardless of metal ion cofactor
J Wieruszewska, A Pawłowicz, E Połomska… - Nature …, 2024 - nature.com
DNAzymes–synthetic enzymes made of DNA—have long attracted attention as RNA-
targeting therapeutic agents. Yet, as of now, no DNAzyme-based drug has been approved …
targeting therapeutic agents. Yet, as of now, no DNAzyme-based drug has been approved …
Molecular affinity rulers: systematic evaluation of DNA aptamers for their applicabilities in ELISA
Many nucleic acid aptamers that bind to target molecules have been reported as antibody
alternatives. However, while the affinities of aptamers vary widely, little is known about the …
alternatives. However, while the affinities of aptamers vary widely, little is known about the …
Structures, kinetics, thermodynamics, and biological functions of RNA hairpins
PC Bevilacqua, JM Blose - Annu. Rev. Phys. Chem., 2008 - annualreviews.org
Most RNA comprises one strand and therefore can fold back on itself to form complex
structures. At the heart of these structures is the hairpin, which is composed of a stem having …
structures. At the heart of these structures is the hairpin, which is composed of a stem having …